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Aggregation and gelation in hydroxypropylmethyl cellulose aqueous solutions
Silva, Sérgio M. C.; Pinto, Fátima V.; Antunes, Filipe E.; Miguel, Maria G.; Sousa, João J. S.; Pais, Alberto A. C. C.http://www.sciencedirect.com/science/article/B6WHR-4TC923M-1/2/012a59092ead1ce270813efcf98c1fb2
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Devel...
Silva, Cláudia L.; Pereira, Jorge C.; Ramalho, Amílcar; Pais, Alberto A. C. C.; Sousa, João J. S.Novel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interact...
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Os...
Costa-Balogh, Fátima O.; Åberg, Christoffer; Sousa, João J. S.; Sparr, EmmaIn this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear tr...
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