Encontrados 22 documentos, a visualizar página 1 de 3
Lipocalin-2 is involved in emotional behaviors and cognitive function
Ferreira, Ana Catarina; Pinto, Vítor; Mesquita, Sandro; Novais, Ashley da Cruz; Sousa, João Carlos; Neves, Margarida Correia; Sousa, NunoLipocalin-2 is involved in emotional behaviors and cognitive function ; Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display a...
Blood-brain-barriers in aging and in Alzheimer's disease
Marques, Fernanda; Sousa, João Carlos; Sousa, Nuno; Palha, Joana AlmeidaThe aging process correlates with a progressive failure in the normal cellular and organ functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and AD there is a general decrease in the capacity of the body to eliminate toxic compounds and, simultaneously, to supply the brain with relevant growth and nutritional factors. The barriers of the brain are targets of this age related...
Neudesin is involved in anxiety behavior : structural and neurochemical correlates
Novais, Ashley da Cruz; Ferreira, Ana C.; Marques, Fernanda; Pêgo, José M.; Cerqueira, João; Pereira, Ana Carla David; Campos, Filipa L.Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/d...
Os jornalistas e a produção noticiosa na imprensa regional: desafios na criaç...
Sousa, João Carlos; Morais, RicardoORGANIZAÇÕES E TRABALHO, n.º37-38, 2012, pp. 89-103 ; O presente artigo resulta da aplicação de um inquérito aos jornalistas de oito jornais regionais, com o objectivo de recolher dados acerca do perfil dos jornalistas e o seu papel no sistema de produção noticiosa. Os jornalistas enquanto principais responsáveis pelo conteúdo dos jornais, nomeadamente pela selecção da informação e construção noticiosa, são im...
Unbiased stereological method to assess proliferation throughout the subependym...
Palha, Joana Almeida; Oliveira, Ana Catarina; Marques, Fernanda; Sousa, Nuno; Sousa, João CarlosThe subependymal zone (SEZ), frequently named as adult subventricular zone (SVZ), is a niche of adult neural stem and progenitor cells that lines a large extension of the lateral ventricles of the brain. The majority of the studies do not analyze the SEZ throughout its entire extension. Instead, studies of cell populations within the SEZ typically focus their analysis on a narrow space between specific bregma c...
Topographical analysis of the subependymal zone neurogenic niche
Falcão, Ana M.; Palha, Joana Almeida; Ferreira, Ana Catarina; Marques, Fernanda Cristina Gomes de Sousa; Sousa, Nuno; Sousa, João CarlosThe emerging model for the adult subependymal zone (SEZ) cell population indicates that neuronal diversity is not generated from a uniform pool of stem cells but rather from diverse and spatially confined stem cell populations. Hence, when analysing SEZ proliferation, the topography along the anterior-posterior and dorsal-ventral axes must be taken into account. However, to date, no studies have assessed SEZ pr...
Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of...
Mesquita, Sandro; Ferreira, A. C.; Sousa, João Carlos; Santos, Nadine Correia; Neves, Margarida Correia; Sousa, Nuno; Palha, Joana AlmeidaIron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach...
The path from the choroid plexus to the subventricular zone: go with the flow!
Falcão, Ana M.; Marques, Fernanda; Novais, Ashley da Cruz; Sousa, Nuno; Palha, Joana Almeida; Sousa, João CarlosIn adult mammals, under physiological conditions, neurogenesis, the process of generating new functional neurons from precursor cells, occurs mainly in two brain areas: the subgranular zone in the dentate gyrus of the hippocampus, and the subventricular zone (SVZ) lining the walls of the brain lateral ventricles. Taking into account the location of the SVZ and the cytoarchitecture of this periventricular neural...
Simulação discreta de ambientes fabris com o recurso a redes de Petri
Sousa, João Carlos Veríssimo Costa Teixeira deDissertação apresentada para obtenção do grau de Mestre em Engenharia Electrotécnica e de Computadores, na Faculdade de Engenharia da Universidade do Porto, sob a orientação do Prof. Doutor Jorge Manuel Pinho de Sousa
Implementação de exposições virtuais em ambiente tridimensional em museus de ci...
Sousa, João Carlos Carvalho Aires deTese de Mestrado. Multimédia. Faculdade de Engenharia. Universidade do Porto. 2011
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