Encontrados 7 documentos, a visualizar página 1 de 1
In vivo friction study of human skin: Influence of moisturizers on different an...
Ramalho, A.; Silva, C. L.; Pais, A. A. C. C.; Sousa, J. J. S.In order to understand the human haptic system, the mechanical characterization of skin contact is an important task. As the skin constitutes itself a surface, it is convenient to describe the problem using a contacting surface analysis, especially concerning the friction which occurs when the skin interacts with other surfaces. Several published works have shown that the analysis of the friction response of th...
Stratum corneum hydration: Phase transformations and mobility in stratum corneu...
Silva, C. L.; Topgaard, D.; Kocherbitov, V.; Sousa, J. J. S.; Pais, A. A. C. C.; Sparr, E.The outermost layer of skin, stratum corneum (SC), functions as the major barrier to diffusion. SC has the architecture of dead keratin filled cells embedded in a lipid matrix. This work presents a detailed study of the hydration process in extracted SC lipids, isolated corneocytes and intact SC. Using isothermal sorption microcalorimetry and relaxation and wideline 1H NMR, we study these systems at varying deg...
Conformational study of ketoprofen by combined DFT calculations and Raman spect...
Vueba, M. L.; Pina, M. E.; Veiga, F.; Sousa, J. J.; Carvalho, L. A. E. Batista deA conformational study of ketoprofen was carried out by both density functional theory (DFT) calculations and Raman spectroscopy. Nine different geometries were found to correspond to energy minimum conformations but only one of them was experimentally detected in the condensed phase spectra. ; http://www.sciencedirect.com/science/article/B6T7W-4HGM796-2/1/6cedf602b0e0b1233ab158acd2f80f23
Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC ...
Vueba, M. L.; Carvalho, L. A. E. Batista de; Veiga, F.; Sousa, J. J.; Pina, M. E.The influence of cellulose ether derivatives on ibuprofen release from matrix tablets was investigated. Raman spectroscopy and differential scanning calorimetry (DSC) experiments were used, in order to examine the compatibility between the matrix components: both excipients and ibuprofen. While both the DSC and Raman results did not detect any incompatibilities, DSC revealed the existence of some drug:excipient...
Influence of cellulose ether polymers on ketoprofen release from hydrophilic ma...
Vueba, M. L.; Carvalho, L. A. E. Batista de; Veiga, F.; Sousa, J. J.; Pina, M. E.The present work reports the study of different ketoprofen:excipient formulations, in order to determine the effect of the polymer substitution and type of diluent on the drug-release mechanism. Substituted cellulose--methylcellulose, hydroxypropylcellulose and hydroxypropylmethylcellulose were used as polymers, while lactose monohydrate and [beta]-cyclodextrin were tested as diluents. Distinct test formulation...
Analysis of formulation effects in the dissolution of ibuprofen pellets
Costa, F. O.; Pais, A. A. C. C.; Sousa, J. J. S.In this work the effects of citric acid and of two common fillers, lactose (soluble) and tricalcium phosphate (insoluble) are examined on the release profiles from pellets, using ibuprofen as a model drug with pH-dependent solubility. Also studied is the dependence of these profiles on the specific surface area, bulk density, apparent density, porosity and porosity parameters (pore size distribution, total pore...
Comparison of dissolution profiles of Ibuprofen pellets
Costa, F. O.; Sousa, J. J. S.; Pais, A. A. C. C.; Formosinho, S. J.In this work we use both model dependent and independent techniques to assess the difference between dissolution profiles in which ibuprofen, in the form of uncoated pellets, is used as a model drug. The choice of a proper regression function, the relevance of the estimated parameters and the influence of the choice of dissolution points in the assessment of differences is discussed. The results obtained via me...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||