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Ultrafiltration of supercoiled plasmid DNA : modeling and application
Morão, A.; Nunes, J. C.; Sousa, Fani; Amorim, M. T. Pessoa de; Escobar, I. C.; Queiroz, J. A.A mass transfer model is proposed for predicting sieving coefficients, Sobs, of supercoiled plasmid DNA (pDNA), in the presence of a salt, in membranes with narrow pores, i.e., pores smaller than the gyration radii of the plasmids to be considered for a certain application. The model assumes that permeation occurs due to plasmid suction at the membrane surface as a result of the convective flow, being the proba...
Development of a model for membrane filtration of long and flexible macromolecu...
Morão, A.; Nunes, J. C.; Sousa, Fani; Amorim, M. T. Pessoa de; Escobar, I. C.; Queiroz, J. A.A model is proposed for predicting the intrinsic rejections of linear flexible molecules, of high molecular dimensions, in microfiltration and ultrafiltration membranes. The developed model is based on the available theory of hindered transport of solutes through narrow pores, assuming that convection is the only relevant transport mechanism. For the application of the model, partition coefficients of the solut...
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