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Mycobacterium tuberculosis strains are differentially recognized by TLRs with a...
Carmona, J. A.; Cruz, Andrea; Teixeira, Lucia de Fatima Moreira; Sousa, Carole Lara Veiga de; Sousa, Jeremy; Osório, Nuno S.; Saraiva, Ana L.Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and...
TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell ...
Coelho, Maria Teixeira; Cruz, Andrea; Carmona, J. A.; Sousa, Carole Lara Veiga de; Pereira, Daniela Maria Ramos; Saraiva, Ana Laura; Veldhoen, MarcThe authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry. ; CD4+ Th1 cells producing IFN-γ are of extreme importance in controlling infections by Mycobacterium tuberculosis both in mice and in men. In addition to IFN-γ-...
Characterization of the in vitro cytokine response of phagocytes to mycobacteria
Sousa, Carole Lara Veiga deDissertação mestrado Ciências (ramo de conhecimento em Genética Molecular) ; Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the main threats to mankind. Despite the intense research on the immune response to tuberculosis, major questions remain unsolved, one of which relates to the fact that the efficacy of the current vaccine, Mycobacterium Bovis BCG, is variable. However, no other exper...
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