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Neuregulin1/ErbB system: importance in the control of cardiovascular function

Lopes-Conceição, L; Dias-Neto, M; Fontes-Sousa, AP; Mendes-Ferreira, P; Maia-Rocha, C; Henriques-Coelho, T; de Keulenaer, G; Leite-Moreira, AF

The family of Neuregulins (NRG), growth factors like epidermal growth factor, is known to induce growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells. This family comprises four members, being NRG1 the most largely studied, particularly at the cardiovascular level. The biological effects of NRG1 in the adult heart are mediated by the tyrosine kinase receptors ErbB. In the adult h...


Breast Cancer Presents With a Paraneoplastic Neurologic Syndrome

Coelho Barata, P; Morgado, J; Sousa, AP; Duarte de Oliveira, S; Custódio, MP; Bruno da Costa, L; Esteves Pena, J

BACKGROUND: Paraneoplastic neurologic syndromes (PNS) pose quite an uncommon neurological complication, affecting less than 1% of patients with breast cancer. Nearly one third of these patients lack detectable onconeural antibodies (ONAs), and improvement in neurologic deficits with concomitant cancer treatments is achieved in less than 30% of cases. CASE PRESENTATION: A 42-year-old, premenopausal woman presen...


Dual use of Diff-Quik-like stains for the simultaneous evaluation of human sper...

Sousa, AP; Tavares, RS; Velez de la Calle, JF; Figueiredo, H; Almeida, V; Almeida-Santos, T; Ramalho-Santos, J

BACKGROUND: Sperm chromatin status and nuclear DNA damage can be detected using well-established assays. However, most techniques are time-consuming and/or involve elaborate protocols and equipment. We have recently developed a simple and fast method to monitor sperm chromatin status in field conditions using the Diff-Quik assay which is employed in fertility clinics to assess sperm morphology with standard bri...


Urotensin II-induced increase in myocardial distensibility is modulated by angi...

Fontes-Sousa AP; Pires AL; Monteiro-Cardoso VF; Leite-Moreira AF


Echocardiographic evaluation including tissue Doppler imaging in New Zealand wh...

Fontes-Sousa AP; Moura C; Carneiro CS; Teixeira-Pinto A; Areias JC; Leite-Moreira AF


Nitric oxide and prostaglandins - important players in endothelin-1 induced myo...

Brás-Silva C; Monteiro-Sousa D; Duarte AJ; Guerra M; Fontes-Sousa AP; Moura C; Areias JC; Leite-Moreira AF


Echocardiographic evaluation including tissue Doppler imaging in New Zealand wh...

Fontes-Sousa AP; Moura C; Carneiro CS; Teixeira-Pinto A; Areias JC; Adelino Leite Moreira


Nitric oxide and prostaglandins - important players in endothelin-1 induced myo...

Brás-Silva C; Monteiro-Sousa D; Duarte AJ; Guerra M; Fontes-Sousa AP; Moura C; Areias JC; Leite-Moreira AF


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia