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Microtubule-associated protein tau is essential for long-term depression in the...

The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hip...

Suicidal behaviour in frontotemporal dementia patients-a retrospective study

Suicidal behaviour in frontotemporal dementia patients-a retrospective study

Citalopram-mediated anxiolysis and differing neurobiological responses in both ...

Disorders such as depression and anxiety exhibit strong sex differences in their prevalence and incidence, with women also differing from men in their response to antidepressants. Furthermore, receptors for corticotrophin releasing hormone (CRHR1) and arginine vasopressin receptor subtype 1b (AVPR1b) are known to contribute to the regulation of mood and anxiety. In the present study, we compared the anxiety pro...

Stress acts cumulatively to precipitate Alzheimer’s disease-like tau pathology ...

Stressful life experiences are likely tiological factors in sporadic forms of Alzheimer’s disease (AD). Many AD patients hypersecrete glucocorticoids (GCs), and their GC levels correlate with the rate of cognitive impairment and extent of neuronal atrophy. Severity of cognitive deficits in AD correlates strongly with levels of perphosphorylated forms of the cytoskeletal protein TAU, an essential mediator of the...

Corticosteroid status influences the volume of the rat cingulate cortex – a mag...

Imbalances in the corticosteroid milieu result in reductions in hippocampal volume in humans and experimental rodents. The functional correlates of these changes include deficits in cognitive performance and regulation of the hypothalamic–pituitary–adre- nal axis. Since other limbic structures which are intricately connected with the hippocampal formation, also play an important role in behavioural and neuroend...

Corticosteroid status influences the volume of the rat cingulate cortex : a magn...

Prova tipográfica (In Press) ; Imbalances in the corticosteroid milieu result in reductions in hippocampal volume in humans and experimental rodents. The functional correlates of these changes include deficits in cognitive performance and regulation of the hypothalamic–pituitary–adrenal axis. Since other limbic structures which are intricately connected with the hippocampal formation, also play an important rol...