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Novel poly(L-lactic acid)/hyaluronic acid macroporous hybrid scaffolds : charac...
Antunes, Joana Costa; Oliveira, Joaquim M.; Reis, R. L.; Soria, Jose Miguel; Gómez Ribelles, J. L.; Mano, J. F.Poly(L-lactic acid), PLLA, a synthetic biodegradable polyester, is widely accepted in tissue engineering. Hyaluronic acid (HA), a natural polymer, exhibits an excellent biocompatibility, influences cell signaling, proliferation, and differentiation. In this study, HA crosslinking was performed by immersion of the polysaccharide in water-acetone mixtures containing glutaraldehyde (GA). The objective of this work...
Proliferation and differentiation of goat bone marrow stromal cells in 3d scaff...
Escobar Ivirico, J. L.; Salmerón-Sánchez, M.; Gómez Ribelles, J. L.; Monleón Pradas, M.; Soria, Jose Miguel; Gomes, Manuela E.; Reis, R. L.; Mano, J. F.We have synthesized methacrylate-endcapped caprolactone networks with tailored water sorption ability, poly(CLMA-co-HEA), in the form of three-dimensional (3D) scaffolds with the same architecture but exhibiting different hydrophilicity character (xHEA50, 0.3, 0.5), and we investigated the interaction of goat bone marrow stromal cells (GBMSCs) with such structures. For this purpose, GBMSCs were seeded and cultu...
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