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Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytoch...
Rodrigues, Cecília M. P.; Solá, Susana; Sharpe, Juanita C.; Moura, José J. G.; Steer, Clifford J.Biochemistry, 2003, 42 (10), pp 3070–3080 DOI: 10.1021/bi026979d ; Bax is a potent pro-apoptotic member of the Bcl-2 protein family that localizes to the mitochondrial membrane during apoptosis. Tauroursodeoxycholic acid (TUDCA) modulates the apoptotic threshold, in part, by preventing Bax translocation both in vitro and in vivo. The mechanisms by which Bax induces and TUDCA inhibits release of cytochrome c ar...
Membrane structural changes support the involvement of mitochondria in the bile...
Solá, Susana; Brito, Maria A.; Brites, Dora; Moura, José J. G.; Rodrigues, CecíliaClin Sci (Lond). 2002 Nov;103(5):475-85 ; The accumulation of toxic bile salts within the hepatocyte plays a key role in organ injury during liver disease. Deoxycholate (DC) and glycochenodeoxycholate (GCDC) induce apoptosis in vitro and in vivo, perhaps through direct perturbation of mitochondrial membrane structure and function. In contrast, ursodeoxycholate (UDC) and its taurine-conjugated form (TUDC) appea...
Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order...
Moura, José J. G.; Rodrigues, Cecília M. P.; Solá, Susana; Brito, Maria A.; Brites, DoraBackground/Aims: Unconjugated bilirubin (UCB) impairs crucial aspects of cell function and induces apoptosis in primary cultured neurones. While mechanisms of cytotoxicity begin to unfold, mitochondria appear as potential primary targets. Methods: We used electron paramagnetic resonance spectroscopy analysis of isolated rat mitochondria to test the hypothesis that UCB physically interacts with mitochondria to i...
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