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Infliximab induced liver injury in Crohn's disease: A challenging diagnosis

Triple Therapy with High-Dose Proton-Pump Inhibitor, Amoxicillin, and Doxycycli...

INTRODUCTION: Helicobacter pylori resistance to antibiotics is steadily increasing and multidrug-resistant strains are common and difficult to eliminate, mainly in countries where bismuth, tetracycline, furazolidone, and rifabutin are unavailable. AIM: To evaluate the efficacy and safety of a triple therapy with proton-pump inhibitor (PPI), amoxicillin, and doxycycline in patients with multidrug-resistant H. py...

NOD2 gene mutations in ulcerative colitis: useless or misunderstood?

PURPOSE: NOD2 mutations have been linked to an increased risk of Crohn's disease and to some of its phenotypes. The association between NOD2 mutations and susceptibility to ulcerative colitis (UC) remains somewhat controversial and potential correlations between these mutations and UC phenotype have not been studied. AIM: To assess whether NOD2 mutations are a risk factor for UC in Portugal and if there are any...

Influência da corrente e granulometria do material de adição nos revestimentos ...

Revestimentos soldados são aplicados com o intuito de prolongar a vida útil de componentes que operam em meios agressivos. Entre os processos de soldagem a deposição por plasma por arco transferido (PTA) tem sido reconhecida pelo processamento de depósitos homogêneos e densos, utilizando material de adição na forma de pó. A união de dois materiais com composições químicas diferentes, como no caso da aplicação d...

Gastric splenosis: a rare cause of digestive bleeding

Rare cause of fever in a patient with ulcerative colitis

Insuficiência Cardíaca, Diarreia e Flushing – Tumor Neuroendócrino?

We present the clinical case of a 76 year-old women, who in February 2008 used the emergency department by diarrhea, anorexia, weight loss, dyspnoea, cough, and flushing. Under the etiologic study had an echocardiogram that revealed major tricuspid regurgitation. Because of suspicion of Carcinoid Syndrome performed a thoraco-abdomino-pelvic CT that showed a mass approximately 3,5 cm at the mesentery root. With ...

CARD15 mutations and colorectal cancer in a South European country

PURPOSE: CARD15 mutations are associated with higher susceptibility to Crohn's disease (CD) and longstanding colonic CD increases the risk of developing colorectal cancer (CRC). The relation between these mutations and sporadic CRC remains controversial. The aim of this study was to assess whether germline and/or somatic CARD15 mutations are risk factors for sporadic CRC in Portugal and whether there are genoty...

CARD15 Mutations and Perianal Fistulating Crohn’s Disease: Correlation and Pred...

BACKGROUND: CARD15 mutations alter bowel immunity and increase susceptibility to Crohn's disease (CD). However, the relation between these mutations and Crohn's perianal fistulas has not been fully clarified. AIMS: To assess whether CARD15 mutations are associated with risk of developing Crohn's perianal fistulas and whether these mutations are predictors of the response of perianal fistulas to antibiotics. M...

Small-bowel capsule endoscopy in patients with suspected Crohn's disease-diagno...

Background. The aim of this work was to assess the value of capsule enteroscopy in the diagnosis of patients with suspected Crohn's Disease (CD). Methods. This was a retrospective study in a single tertiary care centre involving patients undergoing capsule enteroscopy for suspected CD. Patients taking nonsteroidal anti inflammatory drugs during the thirty preceding days or with a follow-up period of less than s...