Introduction. Exposure to allergens is pivotal in determining sensitization and allergic symptoms in individuals. Pollen grain counts in ambient air have traditionally been assessed to estimate airborne allergen exposure. However, the exact allergen content in ambient air is unknown. HIALINE therefore monitored atmospheric concentrations of Betula, Poaceae and Olea pollen grains and matched their major allergen...
Pollen is routinely monitored, but it is unknown whether pollen counts represent allergen exposure. We therefore simultaneously determined olive pollen and Ole e 1 in ambient air in C ordoba, Spain, and Evora, Portugal, using Hirst-type traps for pollen and high-volume cascade impactors for allergen. Pollen from different days released 12-fold different amounts of Ole e 1 per pollen (both locations P < 0.001)....
While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stage...
By an associate inverse subsemigroup of a regular semigroup $S$ we mean a subsemigroup $T$ of $S$ containing a least associate of each $x \in S$, in relation to the natural partial order $\leq_S$ in $S$. In this paper we investigate a class of orthodox monoids with an associate inverse subsemigroup and obtain a known description of uniquely unit regular orthodox semigroups as a corollary. Also, by considering a...
Gastric cancer is the fourth most frequent type of cancer and the second cause of cancer mortality worldwide. The genetic alterations described so far for gastric carcinomas include amplifications and mutations of the c-ERBB2, KRAS, MET, TP53, and c-MYC genes. Chromosomal instability described for gastric cancer includes gains and losses of whole chromosomes or parts of them and these events might lead to oncog...
Exposure to allergens is one of severa1 factors determining sensitization and allergic symptoms in individuals. Exposure to aeroallergens from pollen is assessed by counting allergenic pollen in ambient air. However, proof is lacking that pollen count is representative for allergen exposure. We therefore monitored simultaneously birch, grass and olive pollen counts and their corresponding major pollen allergen...
Publicação pedagógica ; O presente livro é um texto de apoio à unidade curricular Matemática Discreta e tem assim o objectivo de ser uma apresentação simples, mas cuidada, de conceitos e resultados básicos da Teoria de Grafos e da Teoria de Números.
By an associate inverse subsemigroup of a regular semigroup S we mean a subsemigroup T of S containing a least associate of each x ∈ S, in relation to the natural partial order ≤S. We describe the structure of a regular semigroup with an associate inverse subsemigroup, satisfying two natural conditions. As a articular application, we obtain the structure of regular semigroups with an associate subgroup with med...
In 1987, Sullivan characterised the elements of the semigroup NP(X ) generated by the nilpotents in P(X ), the semigroup (under composition) consisting of all partial transformations of a set X . In 1999, Marques-Smith and Sullivan determined all the ideals of NP(X ) for arbitrary X . In this paper, we use that work to describe all the congruences on NP(X ).
Gastric cancer is the forth most frequent malignancy and the second most common cause of cancer death worldwide. DNA methylation is the most studied epigenetic alteration, occurring through a methyl radical addition to the cytosine base adjacent to guanine. Many tumor genes are inactivated by DNA methylation in gastric cancer. We evaluated the DNA methylation status of ANAPC1, CDKN2A and TP53 by methylation-spe...
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