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EGFR amplification and lack of activating mutations in metaplastic breast carci...
Reis Filho, Jorge S.; Pinheiro, Céline; Lambros, M. B. K.; Milanezi, Fernanda; Carvalho, Silvia; Savage, K.; Simpson, Pete T.; Jones, C.; Swift, S.Metaplastic breast carcinomas are reported to harbour epidermal growth factor receptor (EGFR) overexpression in up to 80% of the cases, but EGFR gene amplification is the underlying genetic mechanism in around one-third of these. In this study, EGFR gene amplification as defined by chromogenic in situ hybridization and protein overexpression was examined in a cohort of 47 metaplastic breast carcinomas. Furtherm...
Metaplastic breast carcinomas are basal-like tumours
Reis Filho, Jorge S.; Milanezi, Fernanda; Steele, D.; Savage, K.; Simpson, Pete T.; Nesland, J. M.; Pereira, Emílio M.; Lakhani, Sunil R.Recently, an immunohistochemical panel comprising antibodies against HER2, estrogen receptor (ER), epidermal growth factor receptor (EGFR) and cytokeratin (CK) 5 ⁄ 6 was reported to identify basal-like breast carcinomas, as defined by cDNA microarrays. Our aim was to analyse a series of metaplastic breast carcinomas (MBCs) using this panel plus two other basal markers (CK14 and p63) and progesterone receptor (...
Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 n...
Reis Filho, Jorge S.; Simpson, Pete T.; Martins, Albino; Gartner, Fátima; Schmitt, Fernando C.p63, cytokeratin (CK) 5/6 and CK 14 have been employed in diagnostic pathology as markers of basal, squamous and myoepithelial differentiation in several types of human neoplasms; however, there is scant data on the concurrent expression of these markers in large series of human neoplasms. We analyzed the distribution of these three immunohistochemical markers in 51 normal human tissue samples, 350 carcinomas, ...
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