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Flux Tracking in delivery polymeric systems
Ferreira, J. A.; Oliveira, P. de; Silva, P. M. da; Simon, L.The dynamics of diffusive and stress-induced transport in polymeric delivery systems was investigated. Partial and ordinary differential equations were first written to describe drug release behaviors in Maxwell and Maxwell-Voigt materials. The time constants governing the flux and concentration responses of a permeating species were determined from a Laplace transform solution of the original model. A ”trackin...
Antiparasitic activities of acridone alkaloids from Swinglea glutinosa (Bl.) Merr.
Santos,Djalma A. P. dos; Vieira,Paulo C.; Silva,M. Fátima das G. F. da; Fernandes,João B.; Rattray,Lauren; Croft,Simon L.Eleven acridone alkaloids isolated from Swinglea glutinosa(Bl.) Merr. were examined for in vitroactivity against chloroquine-sensitive Plasmodium falciparum3D7, Trypanosoma brucei rhodesienseSTIB900 and Leishmania donovaniL82. An assay with KB cells was developed in order to compare in vitrotoxicity of alkaloids with the selective action on the parasites. Nine of the compounds had IC50 values ranging from 0.3 t...
Pharmacological Approaches to Antitrypanosomal Chemotherapy
Croft,Simon LThere is an urgent need for new drugs for the chemotherapy of human African trypanosomiasis, Chagas disease and leishmaniasis. Progress has been made in the identification and characterization of novel drug targets for rational chemotherapy and inhibitors of trypanosomatid glycosomal enzymes, trypanothione reductase, ornithine decarboxylase, S-adenosylmethionine decarboxylase, cysteine proteases and of the puri...
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