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Mgp expression and accumulation in heart and kidney of turbot (Scophthalmus max...
Roberto, V.; Cavaco, S.; Simes, Dina; Gavaia, Paulo J.; Cancela, LeonorMatrix γ-carboxyglutamic acid (Gla) protein (Mgp) is a vitamin K-dependent protein normally found associated with the organic matrix of cartilage and bone in vivo. After the discovery of Mgp in various soft tissues, this protein was proposed to act as a local inhibitor of mineralization although its molecular mechanisms of action remain incompletely understood.
Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturg...
Viegas, C. S. B.; Simes, Dina; Laizé, Vincent; Williamson, M. K.; Price, P. A.; Cancela, LeonorWe report the isolation of a novel vitamin K-dependent protein from the calcified cartilage of Adriatic sturgeon (Acipenser nacarii). This 10.2-kDa secreted protein contains 16 -carboxyglutamic acid (Gla) residues in its 74-residue sequence, the highest Gla percent of any known protein, and we have therefore termed it Gla-rich protein (GRP). GRP has a high charge density (36 negative 16 positive 20 net nega...
Isolation and characterisation of metallothionein from the clam Ruditapes decus...
Moura, José J. G.; Simes, Dina C.; Bebianno, Maria JoãoAquatic Toxicology 63 (2003) 307-318 ; Metallothioneins (MT) were obtained after purification from metal-exposed clams (Ruditapes decussatus) using gelpermeation and ion-exchange chromatography. Four cadmium /metallothioneins (CdMTs) were resolved by ionexchange chromatography and they all had similar molecular weights, high cadmium content and an absorption spectra indicative of the presence of characteristic...
Characterization of specific antibodies for fish osteocalcin and its usefulness...
Simes, Dina; Pinto, J. P.; Gavaia, Paulo J.; Cancela, LeonorOsteocalcin (BGP or Bone Gla protein) is a small acidic protein with 46-50 residues (pI»4.0) that belongs to the family of the vitamin K dependent, Gla containing proteins. This protein is the most abundant non-collagenous bone protein in mammals and has been isolated only from bone and dentine suggesting that it may be expressed only in hydroxyapatite-containing bone tissue.
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