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Absence of RKIP expression is an independent prognostic biomarker for gastric c...
Martnho, Olga; Longatto Filho, Adhemar; Reis, R. M.; Simões, Kleber; Jacob, Carlos Eduardo; Zilberstein, Bruno; Bresciani, CláudioGastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in ...
Lymphatic vessel density and VEGF-C expression are significantly different amon...
Garcia, Eduardo Anselmo; Simões, Kleber; Wakamatsu, Alda; Ressio, Rodrigo Albergaria; Alves, Venâncio Avancini Ferreira; Longatto Filho, AdhemarThyroid cancer is the most frequent endocrine neoplasia worldwide. The route for metastasis and loco-regional invasion preferentially occurs by lymphatic vessels. For this reason, the assessment of lymphatic vessel density (LVD) is supposed to represent both a prognostic parameter and also a potential therapeutic target. In order to evaluate the value of LVD in benign and malignant thyroid lesions, we analyzed ...
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