Encontrados 8 documentos, a visualizar página 1 de 1
Gravidez na adolescência
Ambrósio, B; Miranda, M; Simões, C; Costa, C; Barbosa, E; Matos, F
An HPLC-UV method for the measurement of permeability of marker drugs in the Ca...
Kratz,J.M.; Teixeira,M.R.; Koester,L.S.; Simões,C.M.O.The Caco-2 cell line has been used as a model to predict the in vitro permeability of the human intestinal barrier. The predictive potential of the assay relies on an appropriate in-house validation of the method. The objective of the present study was to develop a single HPLC-UV method for the identification and quantitation of marker drugs and to determine the suitability of the Caco-2 cell permeability assay...
Evaluating the interest of making a road safety device with recycled plastics b...
Simões, C. L.; Xará, S. M.; Bernardo, C. A.
Lifestyles in adolescence : substance use and violence
Simões, C.; Matos, M. G.; Batista-Fouget, J.
Comparação das metodologias da Farmacopéia Brasileira para determinação de água...
Borges,D.B.; Farias,M.R.; Simões,C.M.O.; Schenkel,E.P.No presente trabalho foi descrita a comparação da aplicabilidade das metodologias preconizadas na Farmacopéia Brasileira (1988) para a determinação de água em drogas vegetais. Foi realizada, ainda, a validação da determinação de água em analisador de umidade. As matérias-primas vegetais analisadas foram Calendula officinalis L. (calêndula), Foeniculum vulgare Miller (funcho), Maytenus ilicifolia Mart. ex. Reiss...
One year of Lamivudine therapy for portuguese patients with chronic hepatitis B.
Areias, J; Calinas, F; Porto, A; Carvalho, A; Freitas, D; Macedo, G; Noronha, R; Cotter, J; Meliço-Silvestre, A; Peixe, R; Pratas, J; Barrote, DOBJECTIVE: To further verify the efficacy and safety of locally manufactured lamivudine on patients with chronic hepatitis B (CHB). METHODS: 2200 patients with CHB were recruited and received lamivudine orally 100 mg once daily for 12 months. The efficacy assessments included virologic response rate (defined by the absence of serum HBV DNA, HBeAg loss and HBeAg/HBeAb seroconversion), percentage of patients wit...
A pesquisa e a produção brasileira de medicamentos a partir de plantas medicina...
Simões,C. M. O.; Schenkel,E. P.
Unexpected pattern of beta-globin mutations in beta-thalassaemia patients from ...
Cabeda, J.; Correia, C.; Estevinho, A.; Simões, C.; Amorim, M.; Pinho, L.; Justiça, B.We characterized the genetic nature of beta-thalassaemia in northern Portugal. Of the 164 patients studied three were beta-thalassaemia major cases (one IVS-1-6/beta degrees 39 and two homozygous IVS-1-110). The analysis of the frequency of each mutation in the families revealed that the codon 6(-A) mutation was unexpectedly frequent (40%) and associated with the beta-globin haplotype E, and not with the usual ...
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