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Rheological and mechanical properties of acellular and cellladen methacrylated ...
Silva-Correia, J.; Gloria, A.; Oliveira, M. B.; Mano, J. F.; Oliveira, Joaquim M.; Ambrosio, L.; Reis, R. L.Tissue engineered hydrogels hold great potential as nucleus pulposus substitutes (NP), as they promote intervertebral disc (IVD) regeneration and re-establish its original function. But, the key to their success in future clinical applications greatly depends on its ability to replicate the native 3D micro-environment and circumvent their limitation in terms of mechanical performance. In the present study, we i...
Regeneration of the intervertebral disc
Silva-Correia, J.; Pereira, D. R.; Uden, S. van; Oliveira, Joaquim M.; Reis, R. L.Degeneration of intervertebral disc (IVD) seems to be one of the main causes associated to lower back pain (LBP), one of the most common painful conditions that lead to work absenteeism, medical visits, and hospitalization in actual society [1,2]. This complex fibro-cartilaginous structure is composed by two structures, an outer multilayer fiber structure (annulus fibrosus, AF) and a gel-like inner core (nucleu...
Biological evaluation of intervertebral disc cells in different formulations of...
Khang, G.; Lee, S. K.; Kim, H. N.; Silva-Correia, J.; Gomes, Manuela E.; Viegas, C. A. A.; Dias, Isabel R.; Oliveira, Joaquim M.; Reis, R. L.Gellan gum (GG)-based hydrogels are advantageous in tissue engineering not only due to their ability to retain large quantities of water and provide a similar environment to that of natural extracellular matrix (ECM), but also because they can gelify in situ in seconds. Their mechanical properties can be fine-tuned to mimic natural tissues such as the nucleus pulposus (NP). This study produced different formula...
Biocompatibility evaluation of ionic- and photo-crosslinked methacrylated gella...
Silva-Correia, J.; Zavan, B.; Vindigni, V.; Silva, Tiago H.; Oliveira, Joaquim M.; Abatangelo, G.; Reis, R. L.In this study, the stability and biocompatibility of methacrylated gellan gum hydrogels, obtained either by ionic- (iGG-MA) or photo-crosslinking (phGGMA), were evaluated in vitro and in vivo. Size exclusion chromatography analysis of the methacrylated gellan gum (GG-MA) powder revealed that molecular weight is lower as compared to the non-modifi ed material, i.e., low acyl gellan gum. The water uptake and swel...
Functionalisation of methacrylated gellan gum hydrogels by anti-angiogenic dend...
Perugini, V.; Silva-Correia, J.; Oliveira, Joaquim M.; Meikle, S. T.; Guildford, A. L.; Reis, R. L.; Santin, M.The regeneration of cartilage in the intervertebral disc nucleus pulposus and joints is impaired by the formation of fibrocartilage that is caused by the invasion of the tissue by blood vessels. Peptides have been identified by phage display technique which are able to bind VEGF thus inhibiting angiogenesis. The present works focusses on the synthesis of poly(epsilon-lysine) dendrons of three branching generati...
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