Encontrados 17 documentos, a visualizar página 1 de 2
Revealing the potential of squid chitosan-based structures for biomedical appli...
Reys, L. L.; Silva, S. S.; Oliveira, Joaquim M.; Caridade, S. G.; Mano, J. F.; Silva, Tiago H.; Reis, R. L.In recent years, much attention has been given to different marine organisms, namely as potential sources of valuable materials with a vast range of properties and characteristics. In this work, β-chitin was isolated from the endoskeleton of the giant squid Dosidicus gigas and further deacetylated to produce chitosan. Then, the squid chitosan was processed into membranes and scaffolds using solvent casting and ...
Unleashing the potential of supercritical fluids for polymer processing in tiss...
Duarte, Ana Rita C.; Santo, Vitor E.; Alves, A.; Silva, S. S.; Moreira-Silva, Joana; Silva, Tiago H.; Marques, A. P.; Gomes, Manuela E.; Sousa, R. A.One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to move from benchtop to bedside regards biomaterials development, despite the latest advances in polymer processing technologies. A variety of scaffolds processing techniques have been developed and include solvent casting and particles leaching, compression molding and particle leaching, thermally induced pha...
Porous hydrogels from shark skin collagen crosslinked under dense carbon dioxid...
Silva, S. P.; Moreira-Silva, J.; Silva, Tiago H.; Perez-Martin, R. I.; Sotelo, C. G.; Mano, J. F.; Duarte, Ana Rita C.; Reis, R. L.The possibility to fabricate marine collagen porous structures crosslinked with genipin under high pressure carbon dioxide is investigated. Collagen from shark skin is used to prepare prescaffolds by freeze-drying. The poor stability of the structures and low mechanical properties require crosslinking of the structures. Under dense CO2 atmosphere, crosslinking of collagen pre-scaffolds is allowed for 16 h. Addi...
Biomedical exploitation of squid chitosan using particle aggregation derived co...
Reys, L. L.; Silva, S. S.; Pirraco, Rogério; Boutinguiza, M.; Comesaña, R.; Lusquiños, F.; Pou, J.; Mano, J. F.; Silva, Tiago H.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; In the last decades, marine organisms have been the focus of considerable attention as potential source of valuable materials. Some important examples are β-chitin isolated from the endoskeleton of squids and hydroxyapatite (HA) produced from fish-bones. β-chitin is a structural polysaccharide more reactive than th...
Sustained release of prednisone and mesalamine from diatom exoskeletons : bioin...
Zhang, H.; Shahbazi, M. A.; Mäkilä, E. M.; Silva, Tiago H.; Reis, R. L.; Salonen, J. J.; Hirvonen, J. T.; Santos, H. A.Mesoporous silicon and silica-based particles have recently been synthesized and proposed for the controlled delivery of several drugs [1,2]. On the other hand, nature and in particular marine organisms have been the source and inspiration for the development of different biomedical applications, including drug delivery devices [3]. On the border of both rests diatoms exoskeletons, nature-made porous silica-bas...
Polysaccharide-based nanostructured multilayers with distinct sulfated and amin...
Oliveira, S. M.; Silva, Tiago H.; Reis, R. L.; Mano, J. F.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; In vitro cell expansion, differentiation for further cell transplantation and biomaterials-cell fundamental assays are still performed more often on inert 2D surfaces than on 3D culture. 3D systems do not allow an easy cell monitoring and may demand higher cell density, being more costly and time consuming. Inert s...
Fish scales patterning guiding hASC growth
Silva, Joana M.; Afonso, David Losa de Areia; Silva, Tiago H.; Volpato, F.; Motta, A.; Marques, A. P.; Mano, J. F.; Reis, R. L.; Migliaresi, C.Marine organisms and materials exhibit interesting properties for their use in biomedical applications, following biomimetic approaches [1,2]. For instance, the white seabass (Lates Calcarifer) scales exhibit a very interesting pattern, which inspire their use as a guiding platform for cellular growth, in a tissue regeneration approach. Moreover, fish scales are composed of hydroxyapatite and type I collagen fi...
Cartilage regeneration approach based on squid chitosan scaffolds : in-vitro as...
Reys, L. L.; Silva, S. S.; Pirraco, Rogério; Marques, A. P.; Mano, J. F.; Silva, Tiago H.; Reis, R. L.During the past decades, marine organisms have been the focus of considerable attention as potential source of valuable materials. For instance, chitosan is a biopolymer with high potential in the biomedical field and can be produced from crustacean shells and squid pens [1]. In this sense, we propose the use of chitosan to produce scaffolds for regenerative medicine purposes. An alkaline solution was used to d...
Development of marine-based nanocomposite scaffolds for biomedical applications
Reys, L. L.; Silva, S. S.; Boutinguiza, M.; Comesaña, R.; Lusquiños, F.; Pou, J.; Mano, J. F.; Silva, Tiago H.; Reis, R. L.Despite the increasing attention that marine organisms are receiving, many of those are not efficiently exploited and subproducts with valuable compounds are being discarded. Two examples of those subproducts are the endoskeleton of squid, from which β-‐chitin and consecutively chitosan can be obtained; and fish-‐bones, as a source for the production of nano-‐ hydroxyapatite. In this work, inspired in the na...
Biocompatibility evaluation of ionic- and photo-crosslinked methacrylated gella...
Silva-Correia, J.; Zavan, B.; Vindigni, V.; Silva, Tiago H.; Oliveira, Joaquim M.; Abatangelo, G.; Reis, R. L.In this study, the stability and biocompatibility of methacrylated gellan gum hydrogels, obtained either by ionic- (iGG-MA) or photo-crosslinking (phGGMA), were evaluated in vitro and in vivo. Size exclusion chromatography analysis of the methacrylated gellan gum (GG-MA) powder revealed that molecular weight is lower as compared to the non-modifi ed material, i.e., low acyl gellan gum. The water uptake and swel...
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