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Increased breast cancer cell toxicity by palladination of the polyamine analogu...
Silva, Tânia M.; Fiuza, Sonia M.; Marques, Maria P. M.; Lo, Persson; Oredsson, StinaBreast cancer is one of the most common malignant tumor forms among women and many women succumb to their disease. Thus, new anticancer agents that can efficiently improve patient survival are of the utmost importance. In this study, the effects of the polyamine analogues N1,N11-bis(ethyl)norspermine (BENSpm) and N1-cyclo-propylmethyl-N11-ethylnorspermine (CPENSpm) and the synthesized dinuclear complexes Pd2BEN...
New Adducts of Lapachol with Primary Amines
Santos,Mirelly D. F.; Litivack-Junior,José T.; Antunes,Roberto V.; Silva,Tania M. S.; Camara,Celso A.New adducts of lapachol with neat primary aliphatic amines were obtained in a solvent-free reaction in good to reasonable yields (52 to 88%), at room temperature. The new compounds containing a phenazine moiety were obtained from suitable functionalized aminoalkyl compounds, including ethanolamine, 3-propanolamine, 2-methoxy-ethylamine, 3-methoxy-propylamine, n-butylamine and 2-phenetylamine.
Other chemical constituents isolated from Solanum crinitum Lam. (Solanaceae)
Cornelius,Marli T. F.; Carvalho,Mário G. de; Silva,Tania M. S. da; Alves,Cassia C. F.; Siston,Ana P. N.; Alves,Kelly Z.; Sant'Anna,Carlos M. R.The phytochemical investigation of Solanum crinitum Lam led to the isolation from the fruit trichomes of four flavonoids, tiliroside (1), astragalin (2), kaempferol (3), biochanin A-7-O-β-D-apiofuranosyl-(1→5)-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (7), along with 4-hydroxybenzoic acid (12), and four cinnamic acid derivatives, cis- and trans- coumaric acids (10 and 11) and cis- a...
Avaliação da bioatividade dos extratos de cúrcuma (Curcuma longa L., Zingiberac...
Silva Filho,Carlos R. M. da; Souza,Antonio G. de; Conceição,Marta M. da; Silva,Thiago G. da; Silva,Tania M. S.; Ribeiro,Ana P. L.A cúrcuma é o rizoma limpo, em boas condições, seco e moído da Curcuma longa L., uma planta herbácea da família Zingiberaceae. Visando novas alternativas para o controle da esquistossomose, os extratos de Curcuma longa L. foram testados para a avaliação da atividade moluscicida contra caramujos adultos da espécie Biomphalaria glabrata, e toxicidade (ensaio de letalidade com Artemia salina). A oleoresina e o óle...
Chemical composition, botanical evaluation and screening of radical scavenging ...
Silva,Tania M.S.; Camara,Celso A.; Lins,Antonio C.S.; Agra,Maria de Fátima; Silva,Eva M.S.; Reis,Igor T.; Freitas,Breno M.Stingless bees in Brazil are indigenous and found all over the country. Bee pollen is used for its nutritional value in the human diet. It is made up of natural flower pollen mixed with nectar and bee secretions. In order to evaluate the chemical composition, free radical scavenging activity, and botanical origin, sample of pollen loads from stingless bee, Melipona rufiventris (Uruçu amarela) was studied. The E...
New iodine derivatives of flavonol and isoflavone
Carvalho,Mário G. de; Silva,Virginia C. da; Silva,Tânia M.S. da; Camara,Celso A.; Braz-Filho,RaimundoThe reaction of the flavonol 3,7,3', 4'-tetra-O-methylquercetin (1) and of the isoflavone 7,4'-di-O-methylgenistein (2) with alkaline iodine in methanol afforded four new iodine derivatives: 8-iodo-5-hydroxy-3,7,3', 4'-tetramethoxy- flavone (1a) and 6-iodo-5-hydroxy-3,7,3', 4'-tetramethoxyflavone (1b) from 1; 2 afforded a mixture of two compounds, identified as a racemic mixture of (±)-trans-5-hydroxy-2,3,7,4'-...
Analytical Approaches toward Successful Human Cell Metabolome Studies by NMR Sp...
Duarte, Iola F.; Marques, Joana; Ladeirinha, Ana F.; Rocha, Cláudia; Lamego, Inês; Calheiros, Rita; Silva, Tânia M.; Marques, M. Paula M.The aim of this work was to investigate the effects of cell handling and storage on cell integrity and 1H high resolution magic angle spinning (HRMAS) NMR spectra. Three different cell types have been considered (lung tumoral, amniocytes, and MG-63 osteosarcoma cells) in order for sample-dependent effects to be identified. Cell integrity of fresh cells and cells frozen in cryopreservative solution was 70−80%, w...
Spasmolytic activity of lapachol and its derivatives, α and β-lapacho...
Cavalcante,Fabiana A.; Silva,Joelmir L. V.; Carvalho,Viviane M. N.; Camara,Celso A.; Silva,Tania M. S.; Pinto,Ângelo C.; Vargas,Maria D.Lapachol, α and β-lapachone are naphthoquinones extracted from species of Tabebuia that have shown antiinflammatory, antibacterial, anticancer and trypanosomicidal properties. The aim of this work was to investigate the spasmolytic effect of these naphthoquinones on the guinea-pig ileum, since other naphthoquinones are known to depress the contractile activity of smooth muscles. Lapachol, α and &...
Steroidal glycoalkaloids and molluscicidal activity of Solanum asperum Rich. fr...
Silva,Tania M. S.; Camara,Celso A.; Freire,Kristerson R. L.; Silva,Thiago G. da; Agra,Maria de F.; Bhattacharyya,JnanabrataBioassay-guided fractionation of the alkaloidal extract of the green fruits of Solanum asperum afforded a new compound, solanandaine along with solasonine and solamargine. The total crude alkaloids as well as the isolated pure alkaloids exhibited significant molluscicidal activity.
Molluscicidal activity of 2-hydroxy-[1,4]naphthoquinone and derivatives
Camara,Celso A.; Silva,Tania M.S.; da-Silva,Thiago G.; Martins,Rodrigo M.; Barbosa,Ticiano P.; Pinto,Angelo C.; Vargas,Maria D.The toxic profile of lawsone (2-hydroxy-[1,4]naphthoquinone) and a series of [1,4]naphthoquinone derivatives was evaluated against the brine shrimp Artemia salina and against the mollusk Biomphalaria glabrata, the main transmitting vector of schistosomiasis in Brazil. Of the seventeen compounds tested nine fell below the threshold of 100 µg/mL set for potential molluscicidal activity by the World Health Organiz...
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