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Hybrid biodegradable membranes of silane-treated chitosan/soy protein for biome...
Silva, S. S.; Oliveira, Joaquim M.; Benesch, Johan; Caridade, S. G.; Mano, J. F.; Reis, R. L.In recent years, progress in the field of hybrid materials has been accelerated through use of the sol–gel process for creating materials and devices, which benefit from the incorporation of both inorganic and organic components. In this work, organic–inorganic hybrid membranes were prepared from tetraethoxysilane and a blend system composed of chitosan and soy protein. By introducing a small amount of siloxane...
Revealing the potential of squid chitosan-based structures for biomedical appli...
Reys, L. L.; Silva, S. S.; Oliveira, Joaquim M.; Caridade, S. G.; Mano, J. F.; Silva, Tiago H.; Reis, R. L.In recent years, much attention has been given to different marine organisms, namely as potential sources of valuable materials with a vast range of properties and characteristics. In this work, β-chitin was isolated from the endoskeleton of the giant squid Dosidicus gigas and further deacetylated to produce chitosan. Then, the squid chitosan was processed into membranes and scaffolds using solvent casting and ...
An investigation of the potential application of chitosan/aloe-based membranes ...
Silva, S. S.; Popa, Elena G.; Gomes, Manuela E.; Cerqueira, M. T.; Marques, A. P.; Caridade, S. G.; Teixeira, P.; Sousa, Cláudia; Mano, J. F.A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation beh...
Unleashing the potential of supercritical fluids for polymer processing in tiss...
Duarte, Ana Rita C.; Santo, Vitor E.; Alves, A.; Silva, S. S.; Moreira-Silva, Joana; Silva, Tiago H.; Marques, A. P.; Gomes, Manuela E.; Sousa, R. A.One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to move from benchtop to bedside regards biomaterials development, despite the latest advances in polymer processing technologies. A variety of scaffolds processing techniques have been developed and include solvent casting and particles leaching, compression molding and particle leaching, thermally induced pha...
Alternative methodology for chitin/hydroxyapatite composites using ionic liquid...
Silva, S. S.; Duarte, Ana Rita C.; Oliveira, Joaquim M.; Mano, J. F.; Reis, R. L.An alternative, green method was used to develop chitin-based biocomposite (ChHA) materials by an integrated strategy using ionic liquids, supercritical fluid drying, and salt leaching. ChHA matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt and/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had a heterogeneous porous microstructur...
Effect of crosslinking in chitosan/aloe vera-based membranes for biomedical app...
Silva, S. S.; Caridade, S. G.; Mano, J. F.; Reis, R. L.The positive interaction between polysaccharides with active phytochemicals found in medicinal plants may represent a strategy to create active wound dressing materials useful for skin repair. In the present work, blended membranes composed of chitosan (Cht) and Aloe vera gel were prepared through the solvent casting, and were crosslinked with genipin to improve their prop...
In vivo performance of chitosan/soy-based membranes as wound dressing devices f...
Santos, T. C.; Hoering, B.; Reise, Kathrin; Silva, S. S.; Oliveira, Joaquim M.; Mano, J. F.; Castro, António G.; Reis, R. L.; Griensven, Martijn vanWound management represents a major clinical challenge on what concerns healing enhancement and pain control. The selection of an appropriate dressing plays an important role in both recovery and esthetic ap- pearance of the regenerated tissue. Despite the wide range of available dressings, the progress in the wound care market relies on the increasing interest in using natural-based biomedical products. Herein...
Silk hydrogels from non-mulberry and mulberry silkworm cocoons processed with i...
Silva, S. S.; Popa, Elena G.; Gomes, Manuela E.; Oliveira, M. B.; Nayak, S.; Bano, S.; Mano, J. F.; Kundu, S. C.; Reis, R. L.Matrices based on silk fibroin from the non-mulberry silkworm Antheraea mylitta and the mulberry silkworm Bombyx mori have demonstrated good applicability in regenerative medicine. However, the cocoons of A. mylitta are underutilized in part due to their lack of solubility in traditional organic solvents. Therefore, the present work investigates the solubilization and processing of degummed fibers obtained from...
Biomedical exploitation of squid chitosan using particle aggregation derived co...
Reys, L. L.; Silva, S. S.; Pirraco, Rogério; Boutinguiza, M.; Comesaña, R.; Lusquiños, F.; Pou, J.; Mano, J. F.; Silva, Tiago H.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; In the last decades, marine organisms have been the focus of considerable attention as potential source of valuable materials. Some important examples are β-chitin isolated from the endoskeleton of squids and hydroxyapatite (HA) produced from fish-bones. β-chitin is a structural polysaccharide more reactive than th...
Combination of aloe vera improves the biological performance of chitosan membra...
Silva, S. S.; Popa, Elena G.; Gomes, Manuela E.; Cerqueira, M. T.; Marques, A. P.; Caridade, S. G.; Mano, J. F.; Reis, R. L.Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, suppl. 1 (2013) ; In the last years, aloe vera (AV), a tropical plant belonging to theliliaceaefamily, has gained popularity for medical, cosmetic and nutritional purposes. Commercially, AV appears in food supplements, as additive to drinks, coating fruits, moisturizer, and healing agent in cosmetic products, among others uses. The...
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