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Antifungal activity and detailed chemical characterization of Cistus ladanifer ...

The life-threatening mycoses caused by opportunistic fungal pathogens (mainly species from the genus Candida) associated with nosocomial infections, are one of the major health problems in our days. Therefore, it is crucial to identify new compounds, especially natural ones, that are active against the most broaden spectrum of Candida species. Herein, a screening of the antifungal potential of a phenolicextract...

Silver colloidal nanoparticles : effect on matrix composition and structure of ...

Aim : The aim of this study was to assess the effect of different silver nanoparticles (SN) concentrations on the matrix composition and structure of Candida albicans and Candida glabrata biofilms. Methods and Results : Candida biofilms were developed in 6-well microtiter plates during 48 h. After, these biofilms were exposed to 13·5 or 54 μg SN ml−1 for 24 h. Then, extracellular matrices were extracted from bi...

Characterization of phenolic compounds in wild medicinal flowers from Portugal ...

In the present work, the phenolic compounds of Castanea sativa, Filipendula ulmaria and Rosa micrantha flowers from Northeastern Portugal were characterized by HPLC–DAD–ESI/MS. Furthermore, it was performed a screening of their antifungal potential against Candida species (Candida albicans, Candida glabrata, Candida parapsilosis and Candida tropicalis). C. sativa sample gave the highest amount of phenolic comp...

Evaluation of the ability of C. albicans to form biofilm in the presence of pha...

Pseudomonas aeruginosa and Candida albicans are disparate microbial species, but both are known to be opportunistic pathogens frequently associated with nosocomial infections. The aim of this study was to provide a better understanding of the interactions between these microorganisms in dual-species biofilms. Several bacteriophage-resistant P. aeruginosa phenotypes have been isolated and were used in dual-speci...

Candida bracarensis virulence factors

The role of glucose in biofilm formation by species of Candida albicans and can...

Effect of azoles in Candida glabrata biofilms and its relation with ERG genes e...

The occurrence of fungal infections has been significantly increasing, thus contributing to higher morbidity and mortality. The use of broad-spectrum antibiotics, catheters, immunosuppression diseases, chemo and radiotherapy are predisposing factors for invasive fungal infection development. Candida albicans is the predominant species in both health and disease conditions, yet, in the last two decades the numbe...

Influence of glucose on Candida parapsilosis virulence factors

Candida parapsilosis is a pathogenic fungus responsible for a high number of oral candidosis, predominantly due to the growth in a biofilm form on indwelling medical devices. One of the major contributions for C. parapsiloisis virulence is its versatility to adapt to a variety of different environmental factors. The development of Candida biofilms has important clinical repercussions because of their resistance...

Candida biofilms and oral candidosis : treatment and prevention

In recent years, there has been a significant increase in the incidence of human fungal infections (60). A number of factors have been implicated with this increase, but it is generally accepted that the main influences relate to the more widespread provision of new medical practices, such as immunosuppressive therapy and use of broad spectrum antibiotics, and invasive surgical procedures such as solid organ or...

Silver nanoparticles : influence of stabilizing agent and diameter on antifunga...

Aim : The purpose of this work was to evaluate the size-dependent antifungal activity of different silver nanoparticles (SN) colloidal suspensions against Candida albicans and Candida glabrata mature biofilms. Methods and Results:  The research presented herein used SN of three different average sizes (5, 10 and 60 nm), which were synthesized by the reduction of silver nitrate through sodium citrate and which w...