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Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...
Fraga, J. S.; Silva, N. A.; Lourenço, A. S.; Gonçalves, V.; Neves, N. M.; Reis, R. L.; Rodrigues, A. J.; Manadas, B.; Sousa, N.; Salgado, A. J.It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...
Intracellular delivery of methylprednisolone by dendrimer-based nanoparticles i...
Cerqueira, Susana R.; Oliveira, Joaquim M.; Silva, Barbara L.; Silva, N. A.; Mano, J. F.; Sousa, Nuno; Salgado, A. J.; Reis, R. L.Spinal cord injuries (SCI) still remain a major challenge in current biomedical research. In spite of several advances in the understanding of its mechanisms there has not been an equal significant translation into the clinics. As a result, there is no effective treatment that can overcome the biochemical and cellular adverse reactions that lead to a chronic severely impaired condition. One of the first opportu...
Modelo hierárquico bayesiano aplicado na avaliação genética de curvas de cresci...
Silva,N.A.M.; Lima,R.R.; Silva,F.F.; Muniz,J.A.A estimação dos componentes de (co)variância dos parâmetros de modelos de crescimento pode ser feita por vários métodos. A metodologia bayesiana se apresenta como uma forma alternativa de estimação. Foi realizado um estudo, por meio de dados simulados e de dados reais de animais Nelore, para a estimação dos componentes de (co)variância dos parâmetros do modelo de crescimento de Von Bertalanffy, por meio da meto...
Normal flow-mediated vasodilatation of the brachial artery and carotid artery i...
Cabral,M.D.; Teixeira,P.F.S.; Silva,N.A.O.; Morais,F.F.C.; Soares,D.V.; Salles,E.; Henriques,J.M.; Leite,S.P.; Montenegro,C.A.B.; Vaisman,M.Subclinical hypothyroidism (SHT) is a disease for which exact therapeutic approaches have not yet been established. Previous studies have suggested an association between SHT and coronary heart disease. Whether this association is related to SHT-induced changes in serum lipid levels or to endothelial dysfunction is unclear. The aim of this study was to determine endothelial function measured by the flow-mediate...
The association of ACE gene D/I polymorphism with cardiovascular risk factors i...
Cardoso,R.L.; Nogueira,A.R.; Salis,L.H.A.; Ürményi,T.P.; Silva,R.; Moura-Neto,R.S.; Pereira,B.B.; Rondinelli,E.; de Souza e Silva,N.A.Our aim was to determine the frequencies of the angiotensin-converting enzyme (ACE) gene alleles D and I and any associations to cardiovascular risk factors in a population sample from Rio de Janeiro, Brazil. Eighty-four adults were selected consecutively during a 6-month period from a cohort subgroup of a previous large cross-sectional survey in Rio de Janeiro. Anthropometric data and blood pressure measuremen...
Hepatitis C virus seroprevalence and genotypes in patients with diffuse connect...
Barbosa,V.S.; Silva,N.A. da; Martins,R.M.B.Many extrahepatic manifestations, including rheumatic diseases, have been reported to be associated with hepatitis C virus (HCV) infection. In order to investigate the prevalence of HCV infection among patients with rheumatic diseases, in the present study we interviewed 367 patients and tested their blood samples for HCV antibodies (anti-HCV) by an enzyme-linked immunosorbent assay. Anti-HCV-reactive samples w...
Selection for breed-specific growth hormone and IGF-I alleles in a synthetic be...
Regitano,L.C.A.; Azevedo,J.L.; Vencovsky,R.; Packer,I.U.; Barbosa,P.F.; Rosa,A.J.M.; Silva,N.A.; Etchegaray,M.A.L.; Coutinho,L.L.This study was developed to evaluate selection effects on gene frequencies in a synthetic beef cattle cross (5/8 Charolais, 3/8 Zebu) named Canchim. A sample of 154 Canchim animals, representing three generation classes, was analyzed for seven molecular markers. Thirty-six Charolais cattle were also studied for comparison. A highly significant variation (P < 0.01), with a linear increase of the allele coding...
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