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Topical caffeine delivery using biocellulose membranes: a potential innovative ...

In this study, biocellulose (BC) membranes have been investigated as caffeine topical delivery systems, for the potential treatment of cellulite. BC-caffeine membranes were prepared by a simple approach and the permeation of caffeine through human epidermis, from BC or from conventional formulation systems (solution and gel), was compared in vitro to assess their therapeutic applicability. Diffusion studies wit...

Impact of weather conditions on the windows of opportunity for operation of off...

The deployment of offshore wind parks face several challenges. Among them are the difficulties introduced by the atmospheric and sea conditions in accessing those wind parks. A window of opportunity is a timeframe when weather and sea conditions are acceptable and enable to perform specific tasks in the installation and operation/maintenance of the offshore wind park. This study identifies typical time periods ...

A case of systemic pseudohypoaldosteronism with a novel mutation in the SCNN1A ...

We report a neonatal case of systemic pseudohypoaldosteronism type 1 caused by a novel mutation in the SCNN1A gene (homozygous c.1052+2dupT in intron 3) in which the patient presented with life-threatening hyperkalemia, hyponatremia and metabolic acidosis. It remains uncertain if there is genotype-phenotype correlation, due to the rarity of the disease. This mutation, which to our best knowledge has not been de...

Suicídio: um problema de saúde pública

Através da apresentação do panorama epidemiológico do suicídio, pretende-se com este trabalho alertar os profissionais de saúde para a real dimensão do problema. O suicídio é considerado um verdadeiro problema de saúde pública quer na Europa, onde se verificam as maiores taxas de suicídio a nível mundial, quer em Portugal, ocupando este o terceiro lugar, onde o suicídio mais cresceu nos últimos 15 anos. Todos ...

Chemical composition and antibacterial properties of stem and leaf extracts fro...

Prevalence of some virulence factors in Staphylococcus aureus isolated from hea...

Suicidio: um problema de saúde pública

Através da apresentação do panorama epidemiológico do suicídio, pretende-se com este trabalho alertar os profissionais de saúde para a real dimensão do problema. O suicídio é considerado um verdadeiro problema de saúde pública quer na Europa, onde se verificam as maiores taxas de suicídio a nível mundial, quer em Portugal, ocupando este o terceiro lugar, onde o suicídio mais cresceu nos últimos 15 anos. Todos o...

Use of a webcam for movement detection

Bacterial cellulose membranes as transdermal delivery systems for diclofenac: I...

Bacterial cellulose (BC) membranes were explored as novel nanostructured transdermal delivery systems for diclofenac sodium salt (a typical non-steroidal anti-inflammatory drug). Diclofenac sodium salt loaded BC membranes were prepared through a simple methodology, using glycerol as plasticizer, and characterized in terms of structure, morphology and swelling behavior. The membranes were very homogeneous, quite...

Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...

It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...