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The influence of patterned nanofiber meshes on human mesenchymal stem cell oste...
Martins, Albino; Silva, Marta L. Alves da; Faria, Susana, 1972-; Marques, A. P.; Reis, R. L.; Neves, N. M.A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. The biological relevance of P-NFM is demonstrated using hBMSCs as an autologous cell source. The structures induce cell orientation along the uniaxially aligned fibers, mainly during earlier culturing periods under ba...
Evaluation of extracellular matrix formation in polycaprolactone and starch-com...
Silva, Marta L. Alves da; Crawford, Aileen; Mundy, Jenifer; Martins, Albino; Araújo, J. V.; Hatton, Paul V.; Reis, R. L.; Neves, N. M.Cartilage defects are a major health problem. Tissue engineering has developed different strategies and several biomaterial morphologies, including natural-based ones, for repairing these defects. We used electrospun polycaprolactone (PCL) and starch-compounded PCL (SPCL) nanofiber meshes to evaluate extracellular matrix (ECM) formation by bovine articular chondrocytes (BACs). The main aim of this work was to e...
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