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Synthesis of novel Glycoconjugates derived from Alkynyl heterocycles through a ...
Silva, Marília E.; Gonçalves, João Carlos Oliveira; Campos, Ana M. F. Oliveira; Rodrigues, Lígia M.; Esteves, Ana PaulaAccepted author version posted online: 05 Jun 2012 ; The synthesis of a series of novel 1,4-disubstituted 1,2,3-triazole compounds bearing a D-glucose derivative and an heteroaromatic system is described. Alkylation of isatin, 3-methyl-carbazole and one tetrahydro-gamma-carboline with propargyl bromide gave their N-propargyl derivatives in good yields. These compounds further reacted with acetylated D-glucose ...
Synthesis of esters derived from [4-(2-hydroxy-ethyl)-[1,2,3]triazol-1-YL-2,3,4...
Silva, Marília E.; Pinto, T.; Hrdina, R.; Campos, Ana M. F. Oliveira; Rodrigues, Lígia M.; Esteves, Ana Paula2,3,4-Tri-O-benzyl-alpha-D-methylglucoside was prepared and reacted with several acids: benzoic, phenylacetic, 2-(3-bromo-propoxy)-benzoic, acetylsalicylic and 4-(toluene-4-sulfonylamino)-benzoic. The products were isolated with low to fair yields and fully characterized by usual analytical techniques
Synthesis of esters derived from [4-(2-hydroxyethyl)-[1,2,3]triazol-1-yl]-2,3,4...
Pinto, Tiago A. D.; Silva, Marília E.; Cunha, S.; Rodrigues, Lígia M.; Campos, Ana M. F. Oliveira; Hrdina, Radim; Esteves, Ana PaulaThe synthesis of six novel esters containing a triazole ring and an acetylated glucose residue are presented
Naphthotriazole derivatives : synthesis and fluorescence properties
Campos, Ana M. F. Oliveira; Rodrigues, Lígia M.; Esteves, Ana Paula; Silva, Marília E.; Sivasubramanian, Aravind; Hrdina, Radim; Soares, Graça M. B.Eight fluorescent compounds containing a naphthotriazole moiety substituted at position 2 by a (vinylsulfonyl)aryl group or its precursors, containing hydroxyl or sulphonic groups or N-methylglycine, were prepared and characterized. The products were recovered in moderate yields after column chromatography or recrystallization and identified by proton and carbon nuclear magnetic resonance spectroscopy. Double r...
Glicopéptidos fluorescentes : síntese e caracterização
Silva, Marília E.Tese de Doutoramento em Ciências (área de conhecimento Química) ; O objectivo deste trabalho consistiu na síntese de N-glicopéptidos fluorescentes com potencial actividade biológica. Inicialmente preparou-se uma glucosilamina a qual foi ligada a corantes, aminoácidos e a péptidos pela posição anomérica, originando uma ligação amida entre o açúcar e o grupo carboxílico do composto a ligar. Sintetizou-se o pépti...
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