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Neutrophils and macrophages : the main partners of phagocyte cell systems
Silva, Manuel T.; Neves, Margarida CorreiaBiological cellular systems are groups of cells sharing a set of characteristics, mainly key function and origin. Phagocytes are crucial in the host defense against microbial infection. The previously proposed phagocyte cell systems including the most recent and presently prevailing one, the mononuclear phagocyte system (MPS), grouped mononuclear cells but excluded neutrophils, creating an unacceptable situatio...
Corticosteroid-Induced Immunosuppression ultimately does not compromise the eff...
Martins, Teresa G.; Trigo, Gabriela; Fraga, Alexandra G.; Gama, José B.; Longatto Filho, Adhemar; Saraiva, Margarida; Silva, Manuel T.The authors would like to thank Luis Martins, Deolinda Teixeira and Miguel Carneiro for laboratory assistance. Conceived and designed the experiments: TGM MS MTS AGC JP. Performed the experiments: TGM GT AGF JBG ALF. Analyzed the data: TGM ALF MS MTS AGC JP. Contributed reagents/materials/analysis tools: TGM MS MTS AGC JP. Wrote the paper: TGM AGF ALF MS MTS AGC JP. ; Buruli ulcer (BU) is a necrotizing disease...
Local and regional re-establishment of cellular immunity during curative antibi...
Martins, Teresa G.; Gama, José B.; Fraga, Alexandra G.; Saraiva, Margarida; Silva, Manuel T.; Castro, António G.; Pedrosa, JorgeBACKGROUND: Buruli ulcer (BU) is a neglected necrotizing disease of the skin, subcutaneous tissue and bone, caused by Mycobacterium ulcerans. BU pathogenesis is associated with mycolactone, a lipidic exotoxin with cytotoxic and immunosuppressive properties. Since 2004, the World Health Organization recommends the treatment of BU with a combination of rifampicin and streptomycin (RS). Histological analysis of hu...
Cellular immunity confers transient protection in experimental buruli ulcer fol...
Fraga, Alexandra G.; Martins, Teresa G.; Torrado, Egídio; Huygen, Kris; Portaels, Françoise; Silva, Manuel T.; Castro, António G.; Pedrosa, JorgeThe authors would like to thank Luís Martins and Miguel Carneiro for laboratory assistance. Author Contributions Conceived and designed the experiments: AGF AGC JP. Performed the experiments: AGF TGM ET. Analyzed the data: AGF. Contributed reagents/materials/analysis tools: FP. Wrote the paper: AGF KH FP MTS AGC JP. ; BACKGROUND: Buruli ulcer (BU) is an emerging infectious disease caused by Mycobacterium ulcer...
Mycobacterium ulcerans Triggers T-cell immunity followed by local and regional ...
Fraga, Alexandra G.; Cruz, Andrea; Martins, Teresa G.; Torrado, Egídio; Saraiva, Margarida; Pereira, Daniela Maria Ramos; Meyers, Wayne M.Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-...
First cultivation and characterization of mycobacterium ulcerans from the envir...
Portaels, Françoise; Meyers, Wayne M.; Ablordey, Anthony; Castro, António G.; Chemlal, Karim; Rijk, Pim de; Elsen, Pierre; Fissette, KristaBackground: Mycobacterium ulcerans disease, or Buruli ulcer (BU), is an indolent, necrotizing infection of skin, subcutaneous tissue and, occasionally, bones. It is the third most common human mycobacteriosis worldwide, after tuberculosis and leprosy. There is evidence that M. ulcerans is an environmental pathogen transmitted to humans from aquatic niches; however, well-characterized pure cultures of M. ulceran...
Anatypical active cell death process underlies the fungicidal activity of ciclo...
Almeida, Bruno; Sampaio-Marques, Belém; Carvalho, Joana; Silva, Manuel T.; Leão, Cecília; Rodrigues, Fernando José dos Santos; Ludovico, PaulaCiclopirox olamine (CPO), a fungicidal agent widely used in clinical practice, induced in Saccharomyces cerevisiae an active cell death (ACD) process characterized by changes in nuclear morphology and chromatin condensation associated with the appearance of a population in the sub-G0/G1 cell cycle phase and an arrest in the G2/M phases. This ACD was associated neither with intracellular reactive oxygen species ...
Hyperosmotic stress induces metacaspase - and mitochondria - dependent apoptosi...
Silva, Rui D.; Sotoca, Roberto; Johansson, Björn; Ludovico, Paula; Sansonetty, Filipe; Silva, Manuel T.; Peinado, José M.; Côrte-Real, ManuelaProva tipográfica (In Press) ; During the last years, several reports described an apoptosis-like programmed cell death process in yeast in response to different environmental aggressions. Here, evidence is presented that hyperosmotic stress induces in Saccharomyces cerevisiae a cell death process accompanied by morphological and biochemical indicators of apoptotic programmed cell death, namely chromatin conde...
Infection with Mycobacterium ulcerans induces persistent inflammatory responses...
Oliveira, Martinha S.; Fraga, Alexandra G.; Torrado, Egídio; Castro, António G.; Pereira, João P.; Longatto Filho, Adhemar; Milanezi, FernandaBuruli ulcer (BU) is a devastating, necrotizing, tropical skin disease caused by infections with Mycobacterium ulcerans. In contrast to other mycobacterioses, BU has been associated with minimal or absent inflammation. However, here we show that in the mouse M. ulcerans induces persistent inflammatory responses with viru-lence- dependent patterns. Mycolactone-positive, cytotoxic strains are virulent for mice an...
Acetic acid induces a programmed cell death process in the food spoilage yeast ...
Ludovico, Paula; Sansonetty, Filipe; Silva, Manuel T.; Côrte-Real, ManuelaHere we show that 320-800 mM acetic acid induces in Zygosaccharomyces bailii a programmed cell death (PCD) process that is inhibited by cycloheximide, is accompanied by structural and biochemical alterations typical of apoptosis, and occurs in cells with preserved mitochondrial and plasma membrane integrity (as revealed by rhodamine 123 (Rh123) and propidium iodide (PI) staining, respectively). Mitochondrial ul...
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