Encontrados 3 documentos, a visualizar página 1 de 1
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives
Braga, Mara E. M.; Pato, Maria T. Vaz; Silva, Hélio S. R. Costa; Ferreira, Elisabeth I.; Gil, Maria H.; Duarte, Catarina M. M.; Sousa, Hermínio C. deIn this work, three chitosan derivatives (N-carboxymethyl chitosan (CMC), N-carboxybutyl chitosan (CBC) and N-succinyl chitosan (SCC)) were impregnated with flurbiprofen (an anti-inflammatory drug) and timolol maleate (an anti-glaucoma drug), using a supercritical solvent impregnation (SSI) technique (and employing high pressure CO2 and CO2 + EtOH mixtures) in order to develop hydrogel-type ophthalmic drug deli...
Quitosana: derivados hidrossolúveis, aplicações farmacêuticas e avanços
Silva,Hélio S. R. Costa; Santos,Kátia S. C. R. dos; Ferreira,Elizabeth I.Chitin and chitosan are copolymers build from N-acetyl-D-glucosamine and D-glucosamine. The former is widely found in nature and yields the latter on deacetylation. The copolymers are being used for several purposes. Since 1977, when the First International Conference on Chitin and Chitosan was held in Boston, USA, the interest on chitin and chitosan has remarkably increased. This review emphasizes pharmaceutic...
Experimental Determination and Correlation of Artemisinin's Solubility in Super...
Coimbra, Patrícia; Blanco, Miguel R.; Silva, Hélio S. R. Costa; Gil, Maria H.; Sousa, Hermínio C. deThe measurement and correlation of the experimental solubility of the antimalarial artemisinin (Artemisia annua L.) in supercritical carbon dioxide is reported. Results were obtained using a static analytical method at 308.2, 318.2, and 328.2 K, and in a pressure range from 10.0 up to 25.0 MPa. Solubility experimental data were correlated with three density-based models (Chrastil, Bartle, and Méndez-Santiago−Te...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||