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The antiestrogen 4-hydroxytamoxifen protects against isotretinoin-induced perme...
Silva, Filomena S. G.; Ribeiro, Mariana P. C.; Santos, M. S.; Rocha-Pereira, Petronila; Santos-Silva, Alice; Custódio, José B. A.The combination of isotretinoin (13-cis-retinoic acid) with antiestrogens seems to be a promising strategy for cancer chemotherapy. The aim of the study was to evaluate the effects of isotretinoin alone or in combination with 4-hydroxytamoxifen (OHTAM) and with its prodrug tamoxifen (TAM), on the functions of rat liver mitochondria, i.e., mitochondrial permeability transition (MPT), bioenergetic functions and a...
Data: 2013
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Origem: Estudo Geral - Universidade de Coimbra
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