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Mistranslation and telomere stability

The regulation of a stable proteome is crucial for the cell homeostasis. The translation process from the nucleotide sequence of a gene into the aminoacid sequence of a protein is associated with a basal error of 10-4 which the cell deals with through quality control mechanisms. The misincorporation of aminoacids into de novo synthesized proteins tends to rise when the cell is exposed to stressful conditions. T...