Encontrados 11 documentos, a visualizar página 1 de 2
O Que Desencadeia o Sucesso em Alunos com Baixo Rendimento Escolar, no Projeto ...
Azevedo, Joaquim; Gonçalves, Daniela; Gonçalves, José Luís; Silva, Cristina; Nogueira, Isabel Cláudia; Sousa, Júlio; Moreira, Luísa Tavares© Copyright – Escola Superior de Educação Paula Frassinetti; Universidade Católica Portuguesa - Porto
The Monocarboxylate Transporter Inhibitor α-Cyano-4-Hydroxycinnamic Acid Disrup...
Granja, Sara Costa; Santos, Filipa Morais; Gonçalves, Vera M.; Ferreira, Manuel Viana; Nogueira, Rosete; Silva, Cristina Nogueira; Pinto, Jorge CorreiaBACKGROUND/AIMS: The human embryo develops in a hypoxic environment. In this way, cells have to rely on the glycolytic pathway for energy supply, leading to an intracellular accumulation of monocarboxylates such as lactate and pyruvate. These acids have an important role in cell metabolism and their rapid transport across the plasma membrane is crucial for the maintenance of intracellular pH homeostasis. This...
The role of glycoprotein 130 family of cytokines in fetal rat lung development
Silva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho; Veiga, Carla; Moura, Rute S.; Pinto, Jorge CorreiaThe glycoprotein 130 (gp130) dependent family of cytokines comprises interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), cardiotrophin-like cytokine (CLC), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and oncostatin M (OSM). These cytokines share the membrane gp130 as a common signal transducer. Recently, it was demonstrated that IL-6 promotes, whereas LIF inhibits fetal lung branching...
Local fetal lung renin-angiotensin system as a target to treat congenital diaph...
Silva, Cristina Nogueira; Dias, Emanuel Carvalho; Piairo, Paulina C.; Nunes, Susana; Baptista, Maria João Ribeiro Leite; Moura, Rute S.Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT1)...
Leukemia inhibitory factor in rat fetal lung development : expression and funct...
Silva, Cristina Nogueira; Piairo, Paulina C.; Dias, Emanuel Carvalho; Peixoto, Francisca; Moura, Rute S.; Pinto, Jorge CorreiaConceived and designed the experiments: CN-S EC-D JC-P. Performed the experiments: CN-S PP EC-D FOP RSM. Analyzed the data: CN-S PP JC-P. Wrote the paper: CN-S PP RSM JC-P. ; Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) are members of the family of the glycoprotein 130 (gp130)-type cytokines. These cytokines share gp130 as a common signal transducer, which explains why they show some functional re...
The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy res...
Silva, Inês Hilário; Silva, Cristina Nogueira; Figueiredo, Tiago; Lombo, Liliana; Faustino, Ilda; Catarino, Raquel; Nogueira, Augusto; Pereira, DeolindaUncorrected proof ; Aims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the ...
Looking for novel physiological regulators of lung development
Silva, Cristina NogueiraTese de doutoramento em Medicina ; Pediatric and adult diseases characterized by lung hypoplasia or dysplasia are an epidemiological relevant issue, involving important morbidity and mortality rates. The understanding of the complex process of lung development, regulated by several genetic, chemical and physical determinants, has clinical relevance since it can open new perspectives in the treatment of these l...
The apelinergic system in the developing lung : expression and signaling
Piairo, Paulina C.; Moura, Rute S.; Silva, Cristina Nogueira; Pinto, Jorge CorreiaApelin and its receptor APJ constitute a signaling pathway best recognized as an important regulator of cardiovascular homeostasis. This multifunctional peptidergic system is currently being described to be involved in embryonic events which extend into vascular, ocular and heart development. Additionally, it is highly expressed in pulmonary tissue. Therefore, the aim of this study was to investigate the role o...
Análise da exposição tabágica no domicílio e suas repercussões respiratórias em...
Bulhões, Cláudia; Silva, Cristina Nogueira; Ferreira, Daniela; Magalhães, Maria João; Peixoto, VâniaObjectivos: Analisar o grau de exposição tabágica no domicílio e sua relação com a sintomatologia, patologia e função respiratórias em crianças dos 8 aos 10 anos. Métodos: Estudo observacional, transversal, analítico em crianças com idades compreendidas entre os 8 e 10 anos que frequentam o ensino básico na cidade de Braga no ano lectivo de 2006/2007. Foi seleccionada uma amostra de conveniência. As fontes de i...
Avaliação da taxa de cobertura vacinal no Centro de Saúde de Braga, nas coortes...
Silva, Cristina Nogueira; Gonçalves, Jean PierreObjectivo: Determinar a taxa de cobertura vacinal de cada uma das vacinas incluídas no Programa Nacional de Vacinação (PNV), nas coortes de nascimento de 1990 a 2005, no Centro de Saúde Braga (CSB) e nas suas Extensões de Saúde (ES). Tipo de estudo: Estudo observacional, descritivo e transversal. Local: Centro de Saúde de Braga. População: Utentes inscritos em cada uma das ES e US do CSB, nascidos entre o ano d...
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