Encontrados 2 documentos, a visualizar página 1 de 1
Insulin encapsulation in reinforced alginate microspheres prepared by internal ...
Silva, Catarina M.; Ribeiro, António J.; Ferreira, Domingos; Veiga, FranciscoInsulin-loaded alginate microspheres prepared by emulsification/internal gelation were reinforced by blending with polyanionic additive polymers and/or chitosan-coating in order to increase the protection of insulin at simulated gastric pH and obtain a sustained release at simulated intestinal pH. Polyanionic additive polymers blended with alginate were cellulose acetate phtalate (CAP), Eudragit® L100 (EL100), ...
Alginate microspheres prepared by internal gelation: Development and effect on ...
Silva, Catarina M.; Ribeiro, António J.; Figueiredo, Isabel Vitória; Gonçalves, Alexandra Rocha; Veiga, FranciscoRecombinant human insulin was encapsulated within alginate microspheres by the emulsification/internal gelation technique with the objective of preserving protein stability during encapsulation procedure. The influence of process and formulation parameters was evaluated on the morphology and encapsulation efficiency of insulin. The in vitro release of insulin from microspheres was studied under simulated gastro...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||