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Rodent models of heart failure: an updated review
Gomes, A.; Pires, I.; Pires, A.; Silva, Carmen Brás; Moreira, AdelinoHeart failure (HF) is one of the major health and economic burdens worldwide, and its prevalence is continuously increasing. The study of HF requires reliable animal models to study the chronic changes and pharmacologic interventions in myocardial structure and function and to follow its progression toward HF. Indeed, during the past 40 years, basic and translational scientists have used small animal models to ...
Intraventricular pressure gradients in heart failure
Guerra, Miguel; Silva, Carmen Brás; Amorim, Mário; Bento, Cláudia; Bastos, Pedro; Moreira, AdelinoThe aim of the present study was to characterize intraventricular pressure gradients (IVPGs) in an animal model of chronic heart failure. New Zealand rabbits were treated with doxorubicin (heart failure group, n=5) or saline (control group, n=5) and instrumented with pressure catheters placed in the apex and outflow-tract of left ventricle (LV) and with sonomicrometer crystals placed in the apex and base of the...
Enxaqueca: fisiopatologia e factores alimentares desencadeantes
Martins, Margarida; Silva, Carmen BrásA enxaqueca é uma doença neurovascular crónica caracterizada por ataques de cefaleia episódicos e incapacitantes com sintomas autonómicos associados. Os mecanismos relacionados com a sua fisiopatologia ainda não estão completamente esclarecidos, mas a inflamação neurogénica, a alteração no sistema serotoninérgico e a vasodilatação das artérias meníngeas parecem ser os principais responsáveis pela dor. A enxaque...
Força da preensão da mão numa amostra de crianças dos 11 aos 14 Anos
Carreira, Helena; Amaral, Teresa; Silva, Carmen Brás; Oliveira, Bruno; Borges, NunoIntroduction: The determination of hand grip strength is an objective method of evaluation of upper members' integrity. It is also used as a general health indicator. Data about grip strength values in healthy children is useful in the research and diagnosis of diseases that interfere with grip force. The aim of this study was to determine average values of children hand grip strength by age and evaluate its re...
Alpha-Adrenergic Stimulation Increases Myocardial Distensibility Through PKC Ac...
Sousa, Ana Fontes de; Silva, Carmen Brás; Cardoso, Vera Monteiro; Gonçalves, Nádia Pereira; Conceição, Luísa Lopes; Moreira, Adelino Leite[resumo]
O aumento da distensibilidade miocárdica induzido pela Urocortina 2 é dependent...
Silva, Carmen Brás; Almeida, Mónica; Mendes, Susana; Sousa, Ana Fontes de; Moreira, Adelino Leite[abstract] ; [resumo]
Alpha1-adrenergic stimulation decreases myocardial stiffness: a novel PKC media...
Sousa, Ana Fontes de; Conceição, Luísa Lopes; Silva, Carmen Brás; Moreira, Adelino Leite[abstract] ; [resumo]
Inibidores da enzima de conversão da endotelina e sua aplicação na patologia ca...
Cerdeira, Ana; Silva, Carmen Brás; Moreira, Adelino LeiteEndothelin, a potent vasoconstrictor first described in 1988 by Yanagisawa, is an important regulator of cardiovascular function. Hyperactivation of the endothelin system has been implicated in the pathogenesis of various cardiovascular disorders including myocardial infarction, restenosis, hypertension, heart failure and Chagas cardiopathy. Various attempts have been made to suppress this axis. Although promis...
Efeitos Miocárdicos da Endotelina-1
Silva, Carmen Brás; Moreira, Adelino LeiteEndothelin (ET)-1 was originally identified in 1988 as a vasoconstrictor peptide produced by vascular endothelial cells. It is now known that ET-1 can be produced by vascular and endocardial endothelium and by myocardial cells. Activation of endothelin receptors modulates a wide variety of biological processes including vascular tone, growth and myocardial contractile function. In mammals, ET-1's effects are me...
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