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Docking studies in target proteins involved in mechanisms of antibacterial acti...

In the present work, the knowledge on target proteins of standard antibiotics was extended to antimicrobial mushroom compounds. Docking studies were performed for 34 compounds in order to evaluate their affinity to bacterial proteins that are known targets for some antibiotics with different mechanism of action: inhibitors of cell wall synthesis, inhibitors of protein synthesis, inhibitors of nucleic acids synt...

Priapism associated with lumbar stenosis in a dog

Priapism, a persistent long-lasting involuntary erection of the penis, is uncommon in dogs. In this report, the case of a 13-year-old male Pointer, referred to our services due to persistent exposition of the penis, is described. This condition was consecutive to an intermittent priapism situation lasting for several days, which has been initially attributed to the inflammation and haematoma associated with a p...

Margem Oeste Portuguesa

Evaluation of growth inhibitory activity of Crataegus monogyna Jacq. flower bud...

The vast structural diversity of natural compounds found in plants provides unique opportunities for discovering new drugs with possible beneficial effects on human health, including regulation of proliferation and cell death pathways leading to cancer [1]. Crataegus monogyna Jacq. has been studied by our research group to confirm its different alleged health benefits [2-4]. Herein, the antiproliferative activi...

The pinewood nematode, Bursaphelenchus xylophilus, in Madeira Island

The environmental conditions in Madeira Island are favorable for the presence and dissemination of the pinewood nematode (PWN), Bursaphelenchus xylophilus. Five hundred Pinus pinaster wood samples were collected in several forest areas and PWN was detected in 22.8 % of the samples. Bursaphelenchus xylophilus isolates from Madeira Island displayed the species-specific diagnostic characters. A morphological varia...

CCN2/CTGF silencing blocks cell aggregation in embryonal carcinoma P19 cell

Connective tissue growth factor (CCN2/CTGF) is a matricellular-secreted protein involved in extracellular matrix remodeling. The P19 cell line is an embryonic carcinoma line widely used as a cellular model for differentiation and migration studies. In the present study, we employed an exogenous source of CCN2 and small interference RNA to address the role of CCN2 in the P19 cell aggregation phenomenon. Our data...

Persister cells in a biofilm treated with a biocide

This study investigated the physiology and behaviour following treatment with ortho-phthalaldehyde (OPA), of Pseudomonas fluorescens in both the planktonic and sessile states. Steady-state biofilms and planktonic cells were collected from a bioreactor and their extracellular polymeric substances (EPS) were extracted using a method that did not destroy the cells. Cell structure and physiology after EPS extractio...

Degradation kinetics of colour, vitamin C and drip loss in frozen broccoli (Bra...

Studies were undertaken on colour CIE L*a*b* values, vitamin C (ascorbic acid) and drip loss alterations of frozen broccoli (Brassica oleracea L. ssp. Italica) stored at isothermal ( 7, 15, and 25 C) and non-isothermal (accelerated life testing with step-stress methodology; temperature range from 30 to 5 C) conditions. The storage temperatures were selected according to conditions that occur in the cold c...

The effect of abiotic stress pre-treatments on quality attributes of fresh-cut ...

The aim of this study was to evaluate the effects of heat-shock and UV-C radiation stress treatments, applied in whole carrots, on the overall quality of fresh-cut carrot cv. Nantes during storage (5º C).

The relationship between medication adherence and quality of life in people wit...