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Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of...
Silva, Carla G.; Porciúncula, Lisiane O.; Canas, Paula M.; Oliveira, Catarina R.; Cunha, Rodrigo A.Since adenosine A2A receptor (A2ARs) blockade protects against noxious brain insults involving apoptosis, we directly tested if A2AR blockade prevents apoptosis induced by staurosporine (STS). Exposure of rat hippocampal neurons to STS (30 nM, 24 h) decreased neuronal viability while increasing the number apoptotic-like neurons and de-localizing mitochondria and cytochrome c immunoreactivities. This was prevent...
Data: 2007
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Origem: Estudo Geral - Universidade de Coimbra
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