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Intracellular delivery of methylprednisolone by dendrimer-based nanoparticles i...
Cerqueira, Susana R.; Oliveira, Joaquim M.; Silva, Barbara L.; Silva, N. A.; Mano, J. F.; Sousa, Nuno; Salgado, A. J.; Reis, R. L.Spinal cord injuries (SCI) still remain a major challenge in current biomedical research. In spite of several advances in the understanding of its mechanisms there has not been an equal significant translation into the clinics. As a result, there is no effective treatment that can overcome the biochemical and cellular adverse reactions that lead to a chronic severely impaired condition. One of the first opportu...
Hyaluronic acid/poly(amidoamine) dendrimer nanoparticles for central nervous sy...
Silva, Barbara L.; Cerqueira, Susana R.; Fevereiro, J. P.; Pirraco, R. P.; Marques, A. P.; Oliveira, Joaquim M.; Reis, R. L.; Sousa, NunoCentral nervous system (CNS) disorders are among the diseases with less efficiency in treatment. In order to reach its target and exert its effect within the brain parenchyma, drugs must overcome the blood brain barrier (BBB) and the blood-cerebrospinal fluid-brain (BCSFB). The aim of this work was to develop a novel nano-based dendrimer which could serve as a nanocarrier with the ability to cross these barri- ...
Multifunctionalized CMCht/PAMAM dendrimer nanoparticles modulate
Cerqueira, Susana R.; Silva, Barbara L.; Oliveira, Joaquim M.; Mano, J. F.; Sousa, Nuno; Salgado, A. J.; Reis, R. L.The efficiency of the treatments involving CNS disorders is commonly diminished by the toxicity, reduced stability and lack of targeting of the administered neuroactive compounds. In this study, we have successfully multifunctionalized CMCht/PAMAM dendrimer nanoparticles by coupling the CD11b antibody and loading MP into the nanoparticles. The modification of the new antibody-conjugated nanoparticles was confir...
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