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IL-6 and TNF-alpha polymorphisms in portuguese psoriatic patients
Ferreira, J.P.; Torres, T.; Carvalho, C.; Bettencourt, A.; Leal, B.; Vasconcelos, C.; Costa, P.P.; Selores, M.; Silva, B.M.Introduction: Cytokines regulate the growth, function and differentiation of cells and help to steer immune response and inflammation. In this study we focused our attention in two proinflammatory cytokines: IL-6 and TNFa. It is known that their overexpression is responsible for initiation, maintenance and recurrence of skin lesions in psoriatic patients. Therefore, it is important to investigate genetic biomar...
Apoe isoforms in patients with psoriasis
Ferreira, J.C.P.; Torres, T.; Carvalho, C.A.; Bettencourt, A.; Leal, B.; Vasconcelos, C.; Costa, P.P.; Selores, M.; Silva, B.M.Introduction: Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the world population. Patients with psoriasis (Ps) have higher prevalence of lipid disorders when compared to unaffected individuals. These patients, especially those with severe and prolonged disease, have an increased morbidity and mortality from cardiovascular events. Apolipoprotein E (ApoE), a protein involved in lipid metaboli...
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic v...
Kasperavičiute, D.; Catarino, C.B.; Matarin, M.; Leu, C.; Novy, J.; Tostevin, A.; Leal, B.; Hessel, E.V.S.; Hallmann, K.; Hildebrand, M.S.; Dahl, H-H.M.Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe epilepsy with hippocampal sclerosis is frequently associated with important co-morbidities, mandating the search for better understanding and treatment. The cause o...
Organic acids composition of Cydonia oblonga Miller leaf
Oliveira, Andreia P.; Pereira, J.A.; Andrade, P.B.; Valentão, P.; Seabra, R.M.; Silva, B.M.Organic acid profiles of 36 Cydonia oblonga Miller leaf samples, from three different geographical origins of northern (Bragança and Carrazeda de Ansiães) and central Portugal (Covilhã), harvested in three collection months (June, August and October of 2006), were determined by HPLC/UV (214 nm). Quince leaves presented a common organic acid profile, composed of six constituents: oxalic, citric, malic, quinic, s...
Phenolic composition of Cydonia oblonga Miller leaf.
Silva, B.M.; Oliveira, A.P.; Pereira, J.A.; Valentão, P.; Seabra, R.M.; Andrade, P.B.Phenolic profile of 36 Cydonia oblonga Miller leaf samples, from 3 different geographical origins of Portugal, harvested in 3 collection months, was determined by HPLC/DAD. Quince leaf presented a common profile composed by 9 constituents: 3-0-, 4-0- and 5-0-caffeoylquinic acids, 3,5-0-dicaffeoylquinic acid, quercetin-3-0 galactoside, quercetin-3-0-rutinoside, kaempferol-3-0-glycoside, kaempferol-3-0-g1ucoside ...
Phenolic profile of Cydonia oblonga Miller leaves
Oliveira, Andreia P.; Pereira, J.A.; Andrade, P.B.; Valentão, P.; Seabra, R.M.; Silva, B.M.Cydonia oblonga Miller leaves phenolic compounds were analyzed by reversed-phase HPLC/DAD and HPLC/UV. Qualitative and quantitative analysis of phenolics were carried out in a total of 36 samples of quince leaves from three different geographical origins of Northern (Bragança and Carrazeda de Ansiães) and Central Portugal (Covilhã) and three collection months (June, August, and October of 2006). These leaves pr...
Phenolic profile and antioxidative properties of the beefsteak fungus Fistulina...
Silva, B.M.; Ribeiro, Bárbara; Rangel, Joana; Baptista, Paula; Seabra, R.M.The phenolic composition of the edible beefsteak fungus Fistulina hepatica was determined by HPLC/DAD. The results showed a profile composed by caffeic, p-coumaric and ellagic acids, hyperoside and quercetin. Ellagic acid was the main compound in this species. Beefsteak fungus was also investigated for its capacity to act as a scavenger of DPPH radical and reactive oxygen species (superoxide radical, hydroxyl r...
Avaliação da coleção de germoplasma de melancia da Embrapa Hortaliças para tole...
VIEIRA, J. V.; ÁVILA, A. C. de; PINTO, M. N.; SILVA, B. M. da; BORGES, C. L.2005
Phenolic profiles of Portuguese olive fruits (Olea europaea L.): influence of c...
Vinha, A.F.; Ferreres, F.; Silva, B.M.; Valentão, P.; Gonçalves, Artur; Pereira, J.A.; Oliveira, M.B.P.P.; Seabra, R.M.; Andrade, P.B.The phenolic compounds present in 29 samples of olive fruits were analysed by reversed-phase HPLC/DAD and/or HPLC-DAD/ ESI-MS/MS. All samples were collected during the normal picking period for olive oil production, in north and central Portugal, and were obtained from 18 different olive cultivars. Two different extraction methods were necessary for the complete quantification of phenolic compounds, a methanoli...
Analysis and quantification of flavonoidic compounds from Portuguese olive (Ole...
Meirinhos, Julieta; Silva, B.M.; Valentão, P.; Seabra, R.M.; Pereira, J.A.; Dias, A.; Andrade, P.B.; Ferreres, F.Twenty three samples of 18 Portuguese olive leaf cultivars were analysed by a reversed-phase HPLC/DAD procedure and eight flavonoidic compounds were identified and quantified (luteolin 7,40-O-diglucoside, luteolin 7-O-glucoside, rutin, apigenin 7-O-rutinoside, luteolin 40-O-glucoside, luteolin, apigenin and diosmetin). Luteolin 7,40-O-diglucoside and luteolin 40-O-glucoside were identified by HPLC/DAD/MS/MS – E...
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