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Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-ind...
Silva, Ana Paula Ventura; Melo, António; Ferreira, Ana Catarina; Carvalho, M. M.; Campos, Filipa L.; Sousa, Nuno; Pêgo, José M.The extended amygdala, composed by the amygdaloid nuclei and the bed nucleus of the stria terminalis (BNST), plays a critical role in anxiety behavior. In particular, the link between the central nucleus of the amygdala (CeA) and the BNST seems to be critical to the formation of anxiety-like behavior. Chronic unpredictable stress (CUS) exposure is recognized as a validated animal model of anxiety and is known t...
Glucocorticoid programing of the mesopontine cholinergic system
Borges, Sónia Maria de Sousa; Coimbra, Bárbara Guimarães Salazar; Cunha, Carina Isabel Soares da; Silva, Ana Paula Ventura; Pinto, LuísaStress perception, response, adaptation, and coping strategies are individually distinct, and the sequel of stress and/or glucocorticoids (GCs) is also distinct between subjects. In the last years, it has become clear that early life stress is a powerful modulator of neuroendocrine stress-responsive circuits, programing intrinsic susceptibility to stress, and potentiating the appearance of stress-related disord...
Molecular and functional correlates of stress-related anxiety
Silva, Ana Paula VenturaTese de doutoramento em Ciências da Saúde ; Mood disorders, including anxiety or depression, are one of the most prevalent disorders in the modern society. Underlying the etiology of these disorders is, among other factors, a chronic exposure to stress. Stress can be defined as a challenge to the organism’s homeostasis that prepares the organism to a “fight or flight” situation. However, when the stressor is t...
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