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Over-expression of IL-10 by PMT-10 mice: a novel model of myeloproliferative di...

Several cytokines, such as IL-3, IL-6 and IL-12, involved in inflammatory immune responses, have been described as relevant on the modulation of hematopoiesis. However, the role of anti-inflammatory cytokines, like IL-10, has not yet been addressed. We used genetically modified mice that over-express IL-10 under the control of a zinc inducible promoter, PMT-10 mice, to address this question. We show that over-e...