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Regulation by glucose of oscillatory electrical activity and 5-HT/insulin relea...
Antunes, Célia M.; Rosário, Luís M.; Barbosa, Rui M.; Silva, Amélia S.; Baldeiras, Inês E.; Tomé, Ângelo R.; Santos, Rosa M.The glucose sensitivity of bursting electrical activity and pulsatile insulin release from pancreatic islets was determined in absence of functional KATP channels. Membrane potential, [Ca2+]i and 5- HT/insulin release were measured by intracellular recording, fura-2 fluorescence and 5-HT amperometry, respectively. Single mouse islets, bathed in tolbutamide or glibenclamide and high extracellular Ca2+ (Ca2+o), d...
Data: 2008
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Origem: Repositório Científico da Universidade de Évora
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