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Cationic solid lipid nanoparticles (cSLN): Structure, stability and DNA binding...

Optimization of Cationic SLN for Gene Delivery

Fitoquímicos presentes em frutos silvestres

Os frutos silvestres, nomeadamente a amora, o arando vermelho, a framboesa, o mirtilo e a baga de sabugueiro, são particularmente ricos em fitoquímicos (e.g., flavonóides, taninos, polifenóis e ácidos fenólicos) cuja acção biológica se relaciona com protecção antioxidante, cardiovascular, acção anti-envelhecimento e anti-cancerígena. A obtenção de extractos purificados, a sua caracterização química e a elucidaç...

The GLP-1 system

Type-2 diabetes mellitus (T2DM) is a metabolic disease characterized mainly by hyperglycemia, resulting from defects in β-cell function and/or insulin resistance. Treatment approaches include diet, exercise, and pharmacological agents these however can produce adverse effects such as weight gain and hypoglycemia. Glucagon-like peptide-1 (GLP-1) is a peptide hormone that controls glycaemia and preserves β-cell m...

A Note on Regulatory Concerns and Toxicity Assessment in Lipid-Based Delivery S...

A Note on Regulatory Concerns and Toxicity Assessment in Lipid-Based Delivery S...

Glucagon-like peptide 1

O “Glucagon-like peptide 1” (GLP-1), hormona produzida nas células-L intestinais por processamento diferencial do proglucagon, é libertado após ingestão de alimentos. Efeitos de GLP- 1 observam-se, essencialmente, a nível gastrintestinal e pancreático resultando da sua acção directa, ligação ao receptor nas células alvo, ou indirecta, por regulação parácrina. Pelo seu papel na regulação da ingestão de alimentos...

Regulation by glucose of oscillatory electrical activity and 5-HT/insulin relea...

The glucose sensitivity of bursting electrical activity and pulsatile insulin release from pancreatic islets was determined in absence of functional KATP channels. Membrane potential, [Ca2+]i and 5-HT/insulin release were measured by intracellular recording, fura-2 fluorescence and 5-HT amperometry, respectively. Single mouse islets, bathed in tolbutamide or glibenclamide and high extracellular Ca2+ (Ca2+o), di...

Concept study of an implantable microsystem for electrical resistance and tempe...

In cattle breeding industry, where artificial insemination techniques are employed, the successful detection of estrus onset leads to considerable cost-saving in herd management. One of the most reliable approaches is based on the determination of progesterone concentration in milk. However, these methods rely on the biosensor concept where a biological substrate is used in a chemical-binding reaction to direct...

An implantable microsystem for electrical resistance and temperature measuremen...

In the cattle breeding industry, where artificial insemination techniques are employed, the successful detection of oestrus onset leads to considerable cost saving in herd management. One of the most reliable approaches is based on the determination of progesterone concentration in milk. However, these methods rely on the biosensor concept where a biological substrate is used in a chemical binding reaction to, ...