Encontrados 2 documentos, a visualizar página 1 de 1
Indices of Metabolic Dysfunction and Oxidative Stress
Casadesus, Gemma; Moreira, Paula; Nunomura, Akihiko; Siedlak, Sandra; Bligh-Glover, William; Balraj, Elizabeth; Petot, Grace; Smith, Mark; Perry, GeorgeAbstract Metabolic alterations are a key player involved in the onset of Alzheimer disease pathophysiology and, in this review, we focus on diet, metabolic rate, and neuronal size differences that have all been shown to play etiological and pathological roles in Alzheimer disease. Specifically, one of the earliest manifestations of brain metabolic depression in these patients is a sustained high caloric intake...
Redox metals and oxidative abnormalities in human prion diseases
Petersen, Robert; Siedlak, Sandra; Lee, Hyoung-Gon; Kim, Yong-Sun; Nunomura, Akihiko; Tagliavini, Fabrizio; Ghetti, Bernardino; Cras, PatrickPrion diseases are characterized by the accumulation of diffuse and aggregated plaques of protease-resistant prion protein (PrP) in the brains of affected individuals and animals. Whereas prion diseases in animals appear to be almost exclusively transmitted by infection, human prion diseases most often occur sporadically and, to a lesser extent, by inheritance or infection. In the sporadic cases (sporadic Creut...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||