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Signaling pathways influencing tumor microenvironment and their exploitation fo...
Sheeba, Caroline J.; Marslin, Gregory; Revina, Ann Mary; Franklin, GregoryIn the recent years, the “tumor microenvironment” has been receiving growing attention due to its involvement in neoplastic transformation, tumor growth, invasion and protection of tumor cells from host immune response. All these events are facilitated by chemical signals produced by the tumor as well as the surrounding stromal cells. This review is divided into two main parts in which the first part discusses ...
Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy...
Sheeba, Caroline J.; Palmeirim, I.; Andrade, Raquel P.The authors are grateful to Cheryll Tickle and Lewis Wolpert for helpful comments and critical reading of the manuscript, to Lisa Gonc¸alves and Tatiana Resende for fruitful discussions, Rute Moura and Paulina Piairo for technical assistance and Baolin Wang for the kind gift of Gli3 antibody. ; Embryo development requires precise orchestration of cell proliferation and differentiation in both time and space. A...
Poly(D,L-lactic-co-glycolic acid) nanoencapsulation reduces erlotinib-Induced s...
Gregory, Marslin; Sheeba, Caroline J.; Kalaichelvan, V. K.; Manavalan, R.; Reddy, Neelakanta; Gregory, FranklinErlotinib-HCl is a quinazoline derivative used as a drug in the therapy of non-small-cell lung cancer. The present study was conducted to compare the subacute toxicity induced by Erlotinib-HCl delivered to rats as nanoparticles and as free drug. Wistar rats were orally administered with a daily dosage of 200 mg kg−1 Erlotinib-HCl either as free drug or as Poly(D,L-lactic-co-glycolic acid) (PLGA) encapsulated na...
Auxin pretreatment promotes regeneration of sugarcane (Saccharum spp. hybrids) ...
Franklin, Gregory; Arvinth, S.; Sheeba, Caroline J.; Kanchana, M.; Subramonian, N.We have developed a new, simple, quick and genotype-independent method for direct regeneration of sugarcane using novel midrib segment explants. Our protocol involves two steps: the pretreatment of starting material on MS (Murashige and Skoog (1962) Physiol Plant 15:473–497) medium containing 3.0 mg/l 2,4- dichlorophenoxyacetic acid (2,4-D) for 8 days under continuous dark and subsequent transfer of the explant...
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