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Electrochemical Behavior and Determination of Fluconazole
Gil,Éric de S.; Cordeiro,Diogo D.; Matias,Ana E. B.; Serrano,Sílvia H. P.The electrochemical behavior of fluconazole showed an irreversible oxidation process, with the electrochemical - chemical mechanism being highly dependent on the electrode material. Adsorption of reagent at positive applied potential was observed at Pt electrode while preferential adsorption of the oxidation products was observed at Glassy Carbon surfaces. In pH below 7.0, the anodic current process was intensi...
Theoretical and voltammetric studies of 5-Nitro-heterocyclic derivatives with p...
Paula,Fávero R.; Trossini,Gustavo H. G.; Ferreira,Elizabeth I.; Serrano,Silvia H. P.; Menezes,Carla M. S.; Tavares,Leoberto C.Stereoelectronic properties of nitro-heterocyclic bioisosteric congeners were investigated using theory-level quantum chemistry and cyclic voltammetry with the goal of determining physico-chemical properties that affect the redox potential of the nitro group. Molecular geometry, physicochemical properties and stereoelectronic surfaces, such as molecular electrostatic potential, and HOMO and LUMO orbitalar distr...
Rhodium-Prussian Blue modified carbon paste electrode (Rh-PBMCPE) for amperomet...
Ivama,Viviane Midori; Serrano,Silvia H. P.Prussian Blue was deposited at carbon paste electrode surface from a solution containing 2.0 x 10-3 mol L-1 K3[Fe(CN)6], 3.0 x 10-3 mol L-1 FeCl3 and 1.0 x 10-2 mol L-1 HCl using two controlled potentials. To improve the stability of the modified electrode it was 50 times cycled in a solution containing 1.0 x 10-3 mol L-1 RhCl3, 0.50 mol L-1 KCl and 0.010 mol L-1 HCl in the potential range from - 0.40 V to 0.60...
Eletrodos modificados com DNA: uma nova alternativa em eletroanálise
La-Scalea,Mauro A.; Serrano,Silvia H. P.; Gutz,Ivano G. R.The first studies about DNA electrochemistry appeared at the end of the fifties. The voltammetric techniques became important tool for the DNA conformational analysis, producing evidences about DNA double helix polimorphism. The new techniques based on electrodes modification with nucleic acid enlarged the use of the electrochemical methods on the DNA research. DNA electrochemical biosensors are able to detect ...
Voltammetric Behaviour of Metronidazole at Mercury Electrodes
La-Scalea,Mauro A.; Serrano,Silvia H.P.; Gutz,Ivano G.R.Metronidazole is the most important drug of the group of 5-nitroimidazoles and possesses toxicity to anaerobic micro-organisms DNA being the main target for their biological action. The mechanism of biological action of metronidazole is dependent upon the nitro group reduction process. The reduction of metronidazole is pH dependent in acid medium and four electrons are involved in the complete reduction to the ...
An EIS study of DNA-modified electrodes
Brett, Christopher M. A.; Brett, Ana Maria Oliveira; Serrano, Silvia H. P.The preparation and conditioning of DNA-modified electrodes, in which glassy carbon electrodes are covered by a thick film of double-stranded DNA and subsequently conditioned in acetate buffer, has been followed with Electrochemical Impedance Spectroscopy. Spectra were recorded at different values of applied potential in order to probe the alterations occurring in the modifier layer. The alterations in the EIS ...
Flow-injection determination of catechol with a new tyrosinase/DNA biosensor
Dantoni, Patrícia; Serrano, Sílvia H. P.; Brett, Ana Maria Oliveira; Gutz, Ivano G. R.Biosensors find application in flow analysis due to their high selectivity and sensitivity. Decrease in the response during extended use, originated by degradation, inhibition or structural changes of the enzyme or leaching of active components by the flow, is the prevailing problem. As an alternative to additives and preparation techniques cited in the literature, it is proposed to use DNA as a matrix for impr...
Comparison of the voltammetric behavior of metronidazole at a DNA-modified glas...
Brett, Ana Maria Oliveira; Serrano, Silvia H. P.; Gutz, Ivano G. R.; La-Scalea, Mauro A.The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed a similar trend in the reduction mechanism for metronidazole, depenent on pH in the acid and neutral region and independent in alkaline media, although there w...
Electrochemical determination of carboplatin in serum using a DNA-modified glas...
Brett, Ana Maria Oliveira; Serrano, Sílvia H. P.; Macedo, Tice A.; Raimundo, Dulce; Marques, M. Helena; La-Scalea, Mauro A.An electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially...
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