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Os Factores Genéticos na Perda Gestacional

Pregnancy loss is the most common obstetric complication. Multiple factors have been associated with recurrent or sporadic pregnancy loss, and genetic factors, particularly at earlier gestational ages, are the most important ones. The proportion of miscarriages due to chromosomal factors decreases with increasing gestational age. The most common chromosomal abnormalities in early losses are autosomal trisomies,...

Estudo do Aborto Recorrente. Ainda há Lugar para a Histerossalpingografia?

Overview and Aims: The investigation of recurrent miscarriage includes the study of uterine morphology. 3D ultrasound allows the evaluation of the morphology (cavity and outer contour), reducing the need for invasive tests such as hystero - salpingography (HSG), hysteroscopy and laparoscopy. We evaluated the diagnostic agreement between HSG and 3D ultrasound in the study of the uterine cavity morphology. Study ...

Antiphospholipid Syndrome: a Complex Disease

Inferior Vena Cava Filter Placement During Pregnancy: an Adjuvant Option When M...

The authors present a case of a 27-year-old multiparous woman, with multiple thrombophilia, whose pregnancy was complicated with deep venous thrombosis requiring placement of a vena cava filter. At 15th week of gestation, following an acute deep venous thrombosis of the right inferior limb, anticoagulant therapy with low-molecular-weight heparin (LMWH) was instituted without improvement in her clinical status. ...

Sexualidade no Terceiro Trimestre de Gravidez

Objectivos: Descrever a experiência sexual feminina no terceiro trimestre de gravidez. Tipo de estudo: Estudo descritivo transversal. Local: Consulta de Referência da Maternidade Dr. Alfredo da Costa – Lisboa, Portugal. População: Amostra de conveniência de cem mulheres com gravidez de baixo risco, que não tinham restrições médicas na sua actividade sexual. Métodos: As participantes completaram voluntariamente ...

Factor V Leiden and Prothrombin G20210A in Portuguese Women with Recurrent Misc...

OBJECTIVE: To compare the prevalence of factor V Leiden (FVL) and prothrombin (PT) G20210A mutations in Portuguese women with unexplained recurrent miscarriage (RM) and a control group of parous women. MATERIALS AND METHODS: FVL and PT G20210A analysis were carried out in 100 women with three or more consecutive miscarriages and 100 controls with no history of pregnancy losses. Secondary analysis was made rega...

Lupus and Pregnancy. 15 Years of Experience in a Tertiary Center

This retrospective study was designed to evaluate the outcome of pregnancies in women diagnosed with systemic lupus erythematosus (SLE) followed in a tertiary fetal–maternal center. Data were collected from clinical charts between January 1993 and December 2007, with a total of 136 pregnancies (107 patients). Mean maternal age was 29 years, with the vast majority of patients being Caucasian. Most patients were ...

Hipersensibilidade à Varfarina. Que Abordagem?

Os autores descrevem um caso clínico de hipersensibilidade à varfarina traduzido por uma elevação acentuada do INR, aquando da introdução do fármaco em doente com antecedentes tromboembólicos. Da pesquisa de polimorfismos para os genes VKORC1 e CYP2C9, utilizando técnicas de amplificação por PCR e hibridização reversa, apurou-se heterozigotia para -1639G>A (gene VKORC1) e homozigotia para 1075A>C (genótipo CYP2...

Gravidez e Anticorpos Antifosfolípidos em Doentes com Lúpus Eritematoso Sistémi...

Introdução e Objectivo: A presença de anticorpos antifosfolípidos (AAF) está associada a perdas embrionárias e fetais e a outras complicações obstétricas como pré-eclâmpsia, restrição de crescimento intra-uterino e parto pré-termo. Os doentes com lúpus eritematoso sistémico (LES) com frequência possuem AAF e síndroma antifosfolípidica (SAAF) secundária. O objectivo deste estudo é avaliar comparativamente o prog...

Primary Antiphospholipid Syndrome: Pregnancy Outcome in a Portuguese Population

Introduction:Women with antiphospholipid syndrome(APS) may suffer from recurrent miscarriage, fetal death, fetal growth restriction (FGR), pre-eclampsia, placental abruption, premature delivery and thrombosis. Treatment with aspirin and low molecular weight heparin (LMWH) combined with close maternal-fetal surveillance can change these outcomes. Objective: To assess maternal and perinatal outcome in a cohort of...