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Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical ...
Velosa, J; Serejo, F; Bana, T; Redondo, I; Simão, A; Vale, AM; Pires, S; Macedo, G; Marinho, R; Peixe, P; Sarmento, J; Matos, L; Calinas, F; Carvalho, AFrom 1907 patients with chronic hepatitis C proposed for treatment, we analysed 1380 (1124 naive and 256 treatment-experienced) with complete follow-up. Genotype and HCV RNA quantification were assayed by commercial tests. Viremia was considered high if >800,000IU/mL, and low if <400,000IU/mL. Liver fibrosis was staged in 614 patients. RESULTS: Genotype 1 was the most frequent (60%), followed by 3 (25%), 4 (9%)...
Chronic Hepatitis C Treated with Peginterferon alfa plus Ribavirin in Clinical ...
Velosa, J; Serejo, F; Bana, T; Redondo, I; Simão, A; Vale, AM; Pires, S; Macedo, G; Marinho, R; Peixe, P; Sarmento, J; Matos, L; Calinas, F; Carvalho, AFrom 1907 patients with chronic hepatitis C proposed for treatment, we analysed 1380 (1124 naive and 256 treatment-experienced) with complete follow-up. Genotype and HCV RNA quantification were assayed by commercial tests. Viremia was considered high if >800,000IU/mL, and low if <400,000IU/mL. Liver fibrosis was staged in 614 patients. RESULTS: Genotype 1 was the most frequent (60%), followed by 3 (25%), 4 (9%)...
Prevalence of chronic hepatic disease in Portugal. Apropos of a review carried ...
Valente, A I; Unidade de Hepatologia, Serviço de Medicina II, Hospital de Santa Maria, Lisboa.; Almeida, A; Gouveia, A; Serejo, F; Ramalho, FThe chronic elevation of Aminotransferases is one of the most frequent indications for percutaneous Liver Biopsy (LB). From a retrospective study of LB performed in the Hepatology liver Unit of Santa Maria Hospital, between 1989 and 1993, we correlated the histologic diagnosis with the etiology of liver disease, sex, age and the Aspartate aminotransferase/Alanine aminotransferase (AST/ALT) and Gama-Glutamyl tra...
Infection with hepatitis C virus in porphyria cutanea tarda.
Lima, J; Unidade de Hepatologia, Serviço de Medicina II, Hospital de Santa Maria, Lisboa.; Serejo, F; Gloria, H; Ramalho, F; Moura, M CThe authors make a literature review on hepatitis C virus infection in porphyria cutanea tarda, illustrated by one clinical case. They also present some considerations about pathophysiologic mechanisms involved in this association. ; The authors make a literature review on hepatitis C virus infection in porphyria cutanea tarda, illustrated by one clinical case. They also present some considerations about patho...
Chronic hepatitis: the etiological spectrum. The implications for treatment.
Velosa, J; Unidade de Hepatologia, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.; Ramalho, F; Serejo, F; Marinho, R; de Moura, M CThe prevalence of chronic hepatitis and its different aetiologies was studied in all patients above 10 years of age seen in the specialised outpatient clinic of our hospital over a 3 year period. Defining chronic hepatitis as a persistent elevation of the transaminases, 988 patients (62% of all the patients observed) were classified as follows: viral aetiology in 82%, metabolic in 2%, biliary in 2%, alcoholic i...
Therapy of chronic non-A, non-B hepatitis with recombinant interferon alfa and ...
Serejo, F; Unidade de Hepatologia, Universidade de Lisboa (INIC), Hospital de Santa Maria.; Ramalho, F; Marinho, R; Raimundo, M; Velosa, JTo assess the efficacy of therapy with alfa Interferon in chronic hepatitis C (NANB), 18 patients were enrolled in an open trial. Eleven were males and 7 females with a mean age of 43 years. Interferon alfa 2b was used in titrated doses for 9 months and the treatment was started with 5 m.U./Ti. During therapy, the patients were evaluated clinically and biochemically. A liver biopsy was done within 3 months afte...
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