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In Vitro Surfactant Structure-Toxicity Relationships: Implications for Surfacta...

Inácio, Ângela S.; Mesquita, Katia A.; Baptista, Marta; Ramalho-Santos, João; Vaz, Winchil L. C.; Vieira, Otília V.

Background The need for woman-controlled, cheap, safe, effective, easy-to-use and easy-to-store topical applications for prophylaxis against sexually transmitted infections (STIs) makes surfactant-containing formulations an interesting option that requires a more fundamental knowledge concerning surfactant toxicology and structure-activity relationships. Methodology/Principal Findings We report in vitro effect...


In vitro surfactant structure-toxicity relationships: implications for surfacta...

Inácio, Ângela S; Mesquita, Katia A; Jordão, Luísa; Santos, Maria S; Moreno, António J M; Vaz, Winchil L C; Vieira, Otília V

Sexually transmitted infections (STIs) are a major public-health problem worldwide. According to the World Health Organization there are 340 million new cases of bacterial and protozoal STIs (Gonorrhea, Syphilis, Chlamydia and Trichomoniasis) per year. The direct treatment costs and serious perinatal collateral damage caused by STIs represent hefty financial and social burdens, particularly in developing countr...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia