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Both protein kinase G dependent and independent mechanisms are involved in the ...
Sequeira, Sónia M.; Carvalho, Arsélio P.; Carvalho, Caetana M.We compared the effects of sodium nitroprusside (SNP), and of 8-bromo guanosine 3',5'-cyclic monophosphate (8-BrcGMP), on the 4-aminopyridine (4-AP)-evoked Ca2+-dependent release of glutamate from hippocampal nerve terminals and further investigated the role of protein kinase G (PKG) in this mechanism. SNP and 8-BrcGMP dose-dependently inhibited glutamate release, however SNP concentrations ([SNP])>500 [mu]M ab...
Data: 1999
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Origem: Estudo Geral - Universidade de Coimbra
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