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Pulmonary embolism: a diagnostic approach.
Sequeira, J F; Serviço de Medicina I, Hospital de Santa Maria, Lisboa.The diagnosis of pulmonary embolism (PE) has always been a major challenge to hospital practice. As a consequence of the significant failure in diagnosis using clinical criteria alone, more advanced methods like lung scintigraphy and angiography--although unavailable at many clinical centres--have definitely improved the diagnosis efficiency in PE. The author briefly reviews the utility of clinical, analytical,...
Neoplastic hypercoagulability. Apropos of 2 cases with Trousseau syndrome.
Sequeira, J F; Serviço de Medicina I. Hospital de Santa Maria, Lisboa.; Gomes, R M; Gonzalez, M A; Sarmento, J LThe authors describe two cases with venous thromboembolism and neoplasia (ovary and stomach), which also showed evidence of arterial thromboembolic phenomena--cerebrovascular disease in the 1st case and acute myocardial infarction in the 2nd case--favouring the existence of nonbacterial thrombotic endocarditis. This presentation of neoplastic hypercoagulability is frequently underrated in clinical practice. Pat...
The cardiac toxicity of cancer chemotherapy.
Sequeira, J F; Serviço de Medicina I, Hospital de Santa Maria, Lisboa.; Madruga, I M; Ribeiro, M; Duarte, P C; Ferreira, D C; Sarmento, J LThe presence of secondary effects following the administration of chemotherapeutic drugs is an important limitation to cancer therapy. Of these, cardiotoxicity is of crucial importance due to its negative influence on survival. The anthracyclines and cyclophosphamide are the most important cardiotoxic antineoplastic agents currently used. If we agree on a ceiling dosage of chemotherapy we will deprive some pati...
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