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Endothelial dysfunction – a major mediator of diabetic vascular disease
Sena, Cristina M.; Pereira, Ana M.; Seiça, RaquelThe vascular endothelium is a multifunctional organ and is critically involved in modulating vascular tone and structure. Endothelial cells produce a wide range of factors that also regulate cellular adhesion, thromboresistance, smooth muscle cell proliferation, and vessel wall inflammation. Thus, endothelial function is important for the homeostasis of the body and its dysfunction is associated with several pa...
Isoform-specific inhibition of voltage-sensitive Ca2+ channels by protein kinas...
Sena, Cristina M.; Santos, Rosa M.; Standen, Nick B.; Boarder, Michael R.; Rosário, Luís M.Selective protein kinase C (PKC) activators and inhibitors were used to investigate the involvement of specific PKC isoforms in the modulation of voltage-sensitive Ca2+ channels (VSCCs) in bovine adrenal chromaffin cells. Exposure to the phorbol ester phorbol-12,13-dibutyrate (PDBu) inhibited the Ca2+ currents elicited by depolarizing voltage steps. This inhibition was occluded by the PKC-specific inhibitor Ro ...
Regulation of Ca2+ influx by a protein kinase C activator in chromaffin cells: ...
Sena, Cristina M.; Santos, Rosa M.; Boarder, Michael R.; Rosário, Luís M.Phorbol esters reduce depolarization-evoked Ca2+ influx in adrenal chromaffin cells, suggesting that voltage-sensitive Ca2+ channels (VSCCs) are inhibited by protein kinase C-mediated phosphorylation. We now address the possibility that L- and P/Q-type Ca2+ channel subtypes might be differentially involved in phorbol ester action. In bovine chromaffin cells, short-term (10 min) incubations with phorbol 12-myris...
A Toxin Fraction (FTX) from the Funnel-Web Spider Poison Inhibits Dihydropyridi...
Duarte, Carlos B.; Rosário, Luís M.; Sena, Cristina M.; Carvalho, Arsélio P.In adrenal chromaffin cells, depolarization-evoked Ca2+ influx and catecholamine release are partially blocked by blockers of L-type voltage-sensitive Ca2+ channels. We have now evaluated the sensitivity of the dihydropyridine-resistant components of Ca2+ influx and catecholamine release to a toxin fraction (FTX) from the funnel-web spider poison, which is known to block P-type channels in mammalian neurons. FT...
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