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Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high...
Sena, CM; Louro, T; Matafome, P; Nunes, E; Monteiro, P; Seiça, RDiabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial fun...
Disfunção Endotelial na Diabetes Tipo 2: Efeito de Antioxidantes
Sena, CM; Nunes, E; Louro, T; Proença, T; Seiça, RMIndividuals with insulin resistance and diabetes mellitus have increased cardiovascular morbidity and mortality, caused in part by vascular complications. Endothelial dysfunction has been implicated in the pathogenesis of vascular diabetic disease. This abnormal function of the vasculature precedes cardiovascular disease and is associated with impaired endothelium-dependent vasorelaxation. The main etiology of ...
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